Antibiotic resistance genes detected in the marine sponge Petromica citrina from Brazilian coast

Laport, Marinella Silva; Pontes, Paula Veronesi Marinho; Santos, Denise; Santos-Gandelman, Juliana de Fátima; Muricy, Guilherme; Bauwens, Mathieu; Giambiagi-deMarval, Márcia; George, Isabelle

doi:10.1016/j.bjm.2016.04.016

Cited by 12 publications

(5 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The spread of ARB, ARGs, and antibiotics in freshwater occurs not only in the water and sediment but also in biofilms (Proia et al, 2016), and the guts of aquatic animals (Fu et al, 2017), which also affect the marine environment including marine water and sponge species (Chen et al, 2013;Hatosy & Martiny, 2015;Laport et al, 2016). water, and groundwater usually at amounts ranging in the nearest ng/L to a few µg/L (Azanu et al, 2016).…”

Section: Freshwater Bodiesmentioning

confidence: 99%

The incidence of antibiotic resistance within and beyond the agricultural ecosystem: A concern for public health

2020

View full text Add to dashboard Cite

The agricultural ecosystem creates a platform for the development and dissemination of antimicrobial resistance, which is promoted by the indiscriminate use of antibiotics in the veterinary, agricultural, and medical sectors. This results in the selective pressure for the intrinsic and extrinsic development of the antimicrobial resistance phenomenon, especially within the aquaculture‐animal‐manure‐soil‐water‐plant nexus. The existence of antimicrobial resistance in the environment has been well documented in the literature. However, the possible transmission routes of antimicrobial agents, their resistance genes, and naturally selected antibiotic‐resistant bacteria within and between the various niches of the agricultural environment and humans remain poorly understood. This study, therefore, outlines an overview of the discovery and development of commonly used antibiotics; the timeline of resistance development; transmission routes of antimicrobial resistance in the agro‐ecosystem; detection methods of environmental antimicrobial resistance determinants; factors involved in the evolution and transmission of antibiotic resistance in the environment and the agro‐ecosystem; and possible ways to curtail the menace of antimicrobial resistance.

show abstract

Section: Freshwater Bodiesmentioning

confidence: 99%

The incidence of antibiotic resistance within and beyond the agricultural ecosystem: A concern for public health

2020

View full text Add to dashboard Cite

show abstract

“…Despite the description of the exchange of genes between Gram-negative and Gram-positive microorganisms (161,162) and the spread of antibiotic resistance determinants among them (161)(162)(163)(164)(165), prior to 2016, only a few specific Gram-positive TMQR, such as QacBIII, had been detected in Staphylococcus aureus (166). Nonetheless, PCR studies performed in the last years have shown the presence of other TMQR, such as qnrA, qnrB, qnrD, oqxAB, or aac(6=)Ib-cr, in Gram-positive microorganisms (167)(168)(169). Unfortunately, to our knowledge, of these genes, only oqxA and oqxB have been fully validated by DNA sequencing (169).…”

Section: General Overview Of Tmqrmentioning

confidence: 99%

“…TMQR have evolved from a series of genes with an as-yet-unknown physiological function, with their unexpected effect on the final MICs of quinolones benefitting their spread outside their original environment to the whole world. In this scenario, and fueled by the direct, continuous growth selection pressure exerted by quinolones in human, veterinary, and environment settings, further steps in the history of TMQR will include their installation in new genetic structures and their spread to new microorganisms, including a greater presence in Gram-positive microorganisms, as has recently been described (167)(168)(169). More efficient variants that are able to expand or modify their quinolone affinity or to confer higher levels of quinolone resistance will be selected.…”

Section: Tmqr and The Futurementioning

confidence: 99%

Transferable Mechanisms of Quinolone Resistance from 1998 Onward

Ruiz

2019

Clin Microbiol Rev

View full text Add to dashboard Cite

SUMMARY While the description of resistance to quinolones is almost as old as these antimicrobial agents themselves, transferable mechanisms of quinolone resistance (TMQR) remained absent from the scenario for more than 36 years, appearing first as sporadic events and afterward as epidemics. In 1998, the first TMQR was soundly described, that is, QnrA. The presence of QnrA was almost anecdotal for years, but in the middle of the first decade of the 21st century, there was an explosion of TMQR descriptions, which definitively changed the epidemiology of quinolone resistance. Currently, 3 different clinically relevant mechanisms of quinolone resistance are encoded within mobile elements: (i) target protection, which is mediated by 7 different families of Qnr (QnrA, QnrB, QnrC, QnrD, QnrE, QnrS, and QnrVC), which overall account for more than 100 recognized alleles; (ii) antibiotic efflux, which is mediated by 2 main transferable efflux pumps (QepA and OqxAB), which together account for more than 30 alleles, and a series of other efflux pumps (e.g., QacBIII), which at present have been sporadically described; and (iii) antibiotic modification, which is mediated by the enzymes AAC(6′)Ib-cr, from which different alleles have been claimed, as well as CrpP, a newly described phosphorylase.

show abstract

“…The ermB is very common in human and animal microbiomes. From this, the important role of the marine environment in the development of antibiotic resistance and transmission of resistance genes between bacteria remains to be further elucidated [31].…”

Section: Absolute Abundance Of Argsmentioning

confidence: 99%

Distribution of Antibiotic Resistance Genes in Three Different Natural Water Bodies-A Lake, River and Sea

Su¹,

Li²,

Yang

et al. 2020

IJERPH

View full text Add to dashboard Cite

Currently, due to abuse in the use of human antibiotics and the weak regulatory control that the authorities have over sewage discharge and manure management, antibiotic resistance genes (ARGs) have become a new type of environmental pollutant. Three different natural water bodies (Poyang Lake, Haihe River and Qingdao No.1 Bathing Beach seawater) were sampled during the same periods to conduct a longitudinal comparison of distribution. The distribution and expression of 11 ARGs in 20 species were studied, and the correlations between the expression and the distribution of time and space of the ARGs in different water bodies were also analyzed. With the exception of ermA, blaNDM-1 and vanA, which were not detected in seawater, the other ARGs could be detected in all three water bodies. Tetracycline resistance genes (tetC, tetM and tetQ) in the seawater and Haihe River had even reached 100%, and sulfa ARGs (sul1 and sul2) in the seawater and Poyang Lake, as well as sul2 and sul3 in the Haihe River, had also reached 100%. The ARG pollution in Haihe River was much more serious, since 14 and 17 of 20 ARG species were significantly higher compared with seawater and Poyang Lake, respectively. Some ARGs also had a high absolute abundance. The absolute abundance of macrolide resistance genes (ermB) in seawater was as high as 8.61 × 107 copies/L, and the anti-tuberculosis resistant genes (rpoB and katG) in the Haihe River Basin were highly abundant at 1.32 × 106 copies/L and 1.06 × 107 copies/L, respectively. This indicates that ARGs have gradually become more diverse and extensive in natural water bodies. The results of a redundancy analysis (RDA) of the three water bodies showed that although each water body is affected by different factors in space and time, overall, the presence of AGRs is closely related to the production and life of human beings and the migration of animals.

show abstract

Antibiotic resistance genes detected in the marine sponge Petromica citrina from Brazilian coast

Cited by 12 publications

References 30 publications

The incidence of antibiotic resistance within and beyond the agricultural ecosystem: A concern for public health

The incidence of antibiotic resistance within and beyond the agricultural ecosystem: A concern for public health

Transferable Mechanisms of Quinolone Resistance from 1998 Onward

Distribution of Antibiotic Resistance Genes in Three Different Natural Water Bodies-A Lake, River and Sea

Contact Info

Product

Resources

About