High prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae in Western French Guiana

Manca, Maria-Francesca; Rochat-Stettler, Laurence; Carod, Jean-François; Agostini, Camille; Jolivet, Anne

doi:10.1016/j.bjid.2020.04.014

Cited by 4 publications

(5 citation statements)

References 18 publications

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“…Our findings were also in line with those of other studies conducted in China ( 23 , 24 ). However, the prevalence of CT and NG in our study is lower compared to those described in western French Guiana and Brazil ( 25 , 26 ). Prevalence rates may vary widely due to the characteristics of different study samples, including the age of the population, access to basic health services, levels of risky sexual behavior, and cultural traditions.…”

Section: Discussioncontrasting

confidence: 96%

Evaluation of the Predictive Value of Urine Leukocyte Esterase Test in Chlamydia trachomatis and Neisseria gonorrhoeae Infection Among Males Attending HIV/STI Clinics in Guangdong Province, China

Zhao

et al. 2022

Front. Med.

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Leukocyte esterase test (LET) detection is a simple and inexpensive test performed by urinalysis. This study investigated the predictive value of LET for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infection among men attending HIV and sexually transmitted infection (HIV/STI) clinics in Guangdong Province, China. A total of 5,509 urine samples were collected from HIV and sexually transmitted infection clinics in Guangdong Province between 2017 and 2019. Specimens from 5,464 males were tested by both LET and nucleic acid amplification test (NAAT). Of 5,464 males, 497 (9.1%) tested positive for CT or NG by NAAT, with respective prevalence rates of 6.4% (95% confidence interval [95% CI]: 5.8–7.1%) and 3.8% (95% CI: 3.3–4.3%), including 1.2% (95% CI: 0.9–1.4%) co-infected. Compared to the HIV-negative individuals, individuals living with HIV tend to have a higher prevalence of CT, NG and co-infection with CT and NG. The LET sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for CT were 46.4% (95% CI: 41.2–51.7%), 92.0% (95% CI: 91.2–92.7%), 28.4% (95% CI: 24.8–32.1%), and 96.1% (95% CI: 95.6–96.7%), respectively. The LET sensitivity, specificity, PPV, and NPV for NG were 68.4% (95% CI: 62.1–74.7%), 91.8% (95% CI: 91.1–92.6%), 25.0% (95% CI: 21.4–28.5%), and 98.7% (95% CI: 98.3–99%), respectively. Compared to the HIV-negative individuals, higher sensitivity and specificity were observed for HIV-positive individuals, but there was no statistical difference. The incremental cost-effectiveness ratio (ICER) using economic costs per additional person CT positive and NG positive was –$238.74 and –$145.60 compared with LET positive, respectively. LET is a cost-effective test and will be valuable for predicting CT and NG infection, which is highly prevalent in low- and middle-income countries.

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Section: Discussioncontrasting

confidence: 96%

Evaluation of the Predictive Value of Urine Leukocyte Esterase Test in Chlamydia trachomatis and Neisseria gonorrhoeae Infection Among Males Attending HIV/STI Clinics in Guangdong Province, China

Zhao

et al. 2022

Front. Med.

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“…This suggests that the disruptions caused by the COVID 19 pandemic in this border area have hampered normal pregnancy follow-up and that women in that population basin often arrive at the hospital in labor and were never screened for syphilis before, thus paving the way toward congenital infection. A recent study in Saint Laurent du Maroni Hospital's STI clinic found a high incidence of chlamydiasis and gonorrhea (38). Figures 11, 12 show that the incidence of chlamydiasis and Gonorrhea seems to have recently increased both in Saint Laurent and in the health Centers on the French side.…”

Section: Other Sexually Transmitted Infectionsmentioning

confidence: 91%

“…A recent study in Saint Laurent du Maroni Hospital’s STI clinic found a high incidence of chlamydiasis and gonorrhea ( 38 ). Figures 11 , 12 show that the incidence of chlamydiasis and Gonorrhea seems to have recently increased both in Saint Laurent and in the health Centers on the French side.…”

Section: Other Sexually Transmitted Infectionsmentioning

confidence: 99%

“…We have seen that HPV infection prevalence reaches levels that are among the highest in the world, with a high cervical cancer incidence and usually more advanced cancers in women living in remote areas. Gonorrhea, Chlamydia , hepatitis B, and HTLV-1 are common ( 38 ). Great progress has been made to reduce HTLV-1 transmission through breastfeeding ( 54 , 55 ).…”

Section: Summary Findings and “Big Picture” Of Sexually Transmitted I...mentioning

confidence: 99%

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Sexually transmitted infections on the border between Suriname and French Guiana: A scoping review

et al. 2022

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PurposeThe Maroni basin –delineating the border between Suriname and Frnch Guiana— presents sociocultural, geographical and economic circumstances that have been conducive to the circulation of sexually transmitted infections and to delays in diagnosis and care. Given the scarcity of published data, we aimed to describe different sexually transmitted infections along the Maroni and to gain a broader understanding of the epidemiologic situation.MethodsWe conducted a scoping review of the efforts to approach the problem of sexually transmitted infections in this complex border area. Temporal trends were plotted and crude numbers were divided by local population numbers.ResultsFor HIV, despite increasing testing efforts, most patients still present at the advanced HIV stage (median CD4 count at diagnosis is < 20 per mm3), and 25% of patients in Saint Laurent du Maroni were lost to follow-up within 6 years. However, progress on both sides has led to a decline in AIDS cases and mortality. Despite a rapid increase in the 1990’s along the Maroni, the current HIV prevalence seemed lower (0.52%) in the rural villages than in coastal urban centers (> 1%). High risk HPV infection prevalence among women reaches 23.3%. The incidence of gonorrhea was 4.2 per 1,000 population aged 15-59. For chlamydiasis it was 3.4 per 1,000 population aged 15-59. For syphilis, the incidence was 2.5 per 1,000 population aged 15-59. Gonorrhea, chlamydiasis, hepatitis B detection increased over time with greater testing efforts and new diagnostic tests. Since the COVID-19 epidemic, congenital syphilis has dramatically increased in Saint Laurent du Maroni reaching 808 per 100,000 live births.ConclusionSexually transmitted infections seemed more prevalent in Saint Laurent du Maroni –the sole urban center—than in the remote villages along the Maroni. The syndromic approach and the heterogeneity of diagnostic platforms presumably overlook most infections in the region. Therefore, a concerted approach and a shared diagnostic upgrade with molecular diagnosis and rapid diagnostic tests seem necessary to reduce the burden of sexually transmitted infections on both sides of the Maroni. Congenital syphilis resulting from COVID-19 disruption of health services requires urgent attention.

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“…of participants Chlamydia prevalence Ref. Cross-sectional survey Female aged 14–39 years 4149 2% [ 2 ] cross-sectional survey Female patients attending clinic 69 8.7% [ 18 ] Meta-analysis General female population 89,886 (include male) 3.1% [ 4 ] a systematic review and meta-analysis Reproductive age women 17,119 7.8% [ 19 ] a systematic review and meta-analysis General population NA 3.8% [ 20 ] Territory-wide STI and Sexual Health Survey (TeSSHS) General population 535 1.7% [ 21 ] A retrospective study Female patients attending clinic 338 24.3% [ 22 ] A retrospective study Pregnant women 439 4.6% [ 12 ] …”

Section: Epidemiologymentioning

confidence: 99%

Female urogenital chlamydia: Epidemiology, chlamydia on pregnancy, current diagnosis, and treatment

Tjahyadi

Ropii

Tjandraprawira

et al. 2022

Annals of Medicine &Amp; Surgery

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High prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae in Western French Guiana

Cited by 4 publications

References 18 publications

Evaluation of the Predictive Value of Urine Leukocyte Esterase Test in Chlamydia trachomatis and Neisseria gonorrhoeae Infection Among Males Attending HIV/STI Clinics in Guangdong Province, China

Evaluation of the Predictive Value of Urine Leukocyte Esterase Test in Chlamydia trachomatis and Neisseria gonorrhoeae Infection Among Males Attending HIV/STI Clinics in Guangdong Province, China

Sexually transmitted infections on the border between Suriname and French Guiana: A scoping review

Female urogenital chlamydia: Epidemiology, chlamydia on pregnancy, current diagnosis, and treatment

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