Seroprevalence of chikungunya virus infection in five hospitals within Anyigba, Kogi State of Nigeria

Omatola, Cornelius Arome; Onoja, Anyebe Bernard; Fassan, Peter K.; Osaruyi, Stephanie A.; Iyeh, Mercy; Samuel, Matthew; Haruna, Peace U.

doi:10.1016/j.bjid.2020.01.001

Cited by 13 publications

(24 citation statements)

References 23 publications

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“…One of the reported risk factors for acquiring chronic CHIKV disease is being more than 45 years old [ 48 , 57 ]. A similar trend was observed among age groups in studies conducted in India, Singapore, and Nigeria [ 52 , 56 , 58 ]. The relationship between increasing age and CHIKV susceptibility has been attributed to the increased degree of exposure and impaired immune function in the elderly population [ 58 , 59 ].…”

Section: Discussionsupporting

confidence: 84%

“…Interestingly, CHIKV seropositivity was not significantly associated with gender, as indicated by an adjusted OR of 1.0 (95% CI: 0.8–1.3). A study conducted in India reported a similar finding [ 52 ], although other studies showed significant differences in seropositivity by gender [ 56 , 58 ].…”

Section: Discussionmentioning

confidence: 52%

“…The reason the CHIKV seropositivity rate in Mandalay is lower than the other two cities, despite previous reports of the high endemicity of other arboviruses transmitted by similar vectors, is unclear [ 36 – 38 , 55 ]. Both IgG and IgM seropositivity were observed at all the study sites, indicating ongoing infection despite previous exposure, and also suggesting that CHIKV endemicity is maintained within the studied regions [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

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Evidence of Chikungunya virus seroprevalence in Myanmar among dengue-suspected patients and healthy volunteers in 2013, 2015, and 2018

et al. 2021

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Introduction Chikungunya virus (CHIKV) is a mosquito-borne virus known to cause acute febrile illness associated with debilitating polyarthritis. In 2019, several institutions in Myanmar reported a CHIKV outbreak. There are no official reports of CHIKV cases between 2011 and 2018. Therefore, this study sought to determine the seroprevalence of CHIKV infection before the 2019 outbreak. Methods A total of 1,544 serum samples were collected from healthy volunteers and patients with febrile illnesses in Yangon, Mandalay, and the Myeik district in 2013, 2015, and 2018. Participants ranged from one month to 65 years of age. Antibody screening was performed with in-house anti-CHIKV IgG and IgM ELISA. A neutralization assay was used as a confirmatory test. Results The seroprevalence of anti-CHIKV IgM and anti-CHIKV IgG was 8.9% and 28.6%, respectively, with an overall seropositivity rate of 34.5%. A focus reduction neutralization assay confirmed 32.5% seroprevalence of CHIKV in the study population. Age, health status, and region were significantly associated with neutralizing antibodies (NAbs) and CHIKV seropositivity (p < 0.05), while gender was not (p = 0.9). Seroprevalence in 2013, 2015, and 2018 was 32.1%, 28.8%, and 37.3%, respectively. Of the clinical symptoms observed in participants with fevers, arthralgia was mainly noted in CHIKV-seropositive patients. Conclusion The findings in this study reveal the circulation of CHIKV in Myanmar’s Mandalay, Yangon, and Myeik regions before the 2019 CHIKV outbreak. As no treatment or vaccine for CHIKV exists, the virus must be monitored through systematic surveillance in Myanmar.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 99%

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Evidence of Chikungunya virus seroprevalence in Myanmar among dengue-suspected patients and healthy volunteers in 2013, 2015, and 2018

et al. 2021

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“…There were no studies examining YFV. Included studies consisted of 2 cohort studies,16 17 4 case–control studies,18–21 27 cross-sectional studies,22–48 1 nested cross-sectional study within a cohort,49 1 combined cross-sectional and cohort study50 and 1 longitudinal serosurvey 51. Studies were conducted in 23 countries: 4 in low-income countries (Burkina Faso,42 Laos35 and Sudan26 43), 14 in lower-middle-income countries (Ecuador,41 India,19 Jordan,33 37 Kenya,17 36 Nicaragua,16 50 Nigeria,27 31 40 Pakistan,39 Sri Lanka18 and Vietnam34), 13 in upper-middle income (Brazil,23 30 45–47 China,20 24 38 Colombia,49 51 Malaysia,25 Paraguay44 and Thailand29) and 5 in high-income countries/territories (Mayotte (France),28 French Guiana,21 Saudi Arabia,22 Sweden32 and USA48) according to the Development Assistance Committee List of Official Development Assistance Recipients (figure 2).…”

Section: Resultsmentioning

confidence: 99%

Socioeconomic risk markers of arthropod-borne virus (arbovirus) infections: a systematic literature review and meta-analysis

et al. 2022

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IntroductionArthropod-borne viruses (arboviruses) are of notable public health importance worldwide, owing to their potential to cause explosive outbreaks and induce debilitating and potentially life-threatening disease manifestations. This systematic review and meta-analysis aims to assess the relationship between markers of socioeconomic position (SEP) and infection due to arboviruses with mosquito vectors.MethodsWe conducted a systematic search on PubMed, Embase, and LILACS databases to identify studies published between 1980 and 2020 that measured the association of SEP markers with arbovirus infection. We included observational studies without geographic location or age restrictions. We excluded studies from grey literature, reviews and ecological studies. Study findings were extracted and summarised, and pooled estimates were obtained using random-effects meta-analyses.ResultsWe identified 36 observational studies using data pertaining to 106 524 study participants in 23 geographic locations that empirically examined the relationship between socioeconomic factors and infections caused by seven arboviruses (dengue, chikungunya, Japanese encephalitis, Rift Valley fever, Sindbis, West Nile and Zika viruses). While results were varied, descriptive synthesis pointed to a higher risk of arbovirus infection associated with markers of lower SEP, including lower education, income poverty, low healthcare coverage, poor housing materials, interrupted water supply, marital status (married, divorced or widowed), non-white ethnicities and migration status. Pooled crude estimates indicated an increased risk of arboviral infection associated with lower education (risk ratio, RR 1.5 95% CI 1.3 to 1.9); I2=83.1%), interruption of water supply (RR 1.2; 95% CI 1.1 to 1.3; I2=0.0%) and having been married (RR 1.5 95% CI 1.1 to 2.1; I2=85.2%).ConclusionEvidence from this systematic review suggests that lower SEP increases the risk of acquiring arboviral infection; however, there was large heterogeneity across studies. Further studies are required to delineate the relationship between specific individual, household and community-level SEP indicators and arbovirus infection risks to help inform targeted public health interventions.PROSPERO registration numberCRD42019158572.

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“…Chikungunya virus (CHKV) was first isolated and characterized in 1953 during an epidemic of febrile polyarthritis in Tanzania [27]. From then onward, several findings have shown the serological evidence of ZIKV infections, including in Nigeria [28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Temporal Evaluation of Insecticide Resistance in Populations of the Major Arboviral Vector Aedes Aegypti from Northern Nigeria

Mukhtar

Ibrahim

2022

Insects

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To support evidence-based control measures, two Nigerian Aedes populations (BUK and Pantami) were characterised. Larval bioassay using temephos and deltamethrin revealed a significant increase in deltamethrin resistance, with LC50 of 0.018mg/L (resistance ratio compared to New Orleans, RR = 2.250) in 2018 increasing ~6-fold, by 2019 (LC5 0 = 0.100mg/L, RR = 12.5), and ~11-fold in 2020 (LC50 = 0.198mg/L, RR = 24.750). For the median deltamethrin concentration (0.05mg/L), a gradual decrease in mortality was observed, from 50.6% in 2018, to 44.9% in 2019, and 34.2% in 2020. Extremely high DDT resistance was observed, with <3% mortalities and LT50s of 352.87min, 369.19min and 406.94 min in 2018, 2019 and 2020, respectively. Significant temporal increase in resistance was observed towards ƛ-cyhalothrin (a type II pyrethroid) over three years. Synergist bioassays with diethylmaleate and piperonylbutoxide significantly recovered DDT and ƛ-cyhalothrin susceptibility respectively, implicating glutathione S-transferases and CYP450s. Cone bioassays revealed increased resistance to the PermaNet®3.0, side panels (mortalities of 94% in 2018, 66.4% in 2019, and 73.6% in 2020), while full susceptibility was obtained with the roof of PermaNet®3.0. The F1534C kdr mutation occurred in low frequency, with significant correlation between heterozygote genotypes and DDT resistance. This temporal increase in resistance is a major challenge for control of this vector of public health importance.

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Seroprevalence of chikungunya virus infection in five hospitals within Anyigba, Kogi State of Nigeria

Cited by 13 publications

References 23 publications

Evidence of Chikungunya virus seroprevalence in Myanmar among dengue-suspected patients and healthy volunteers in 2013, 2015, and 2018

Evidence of Chikungunya virus seroprevalence in Myanmar among dengue-suspected patients and healthy volunteers in 2013, 2015, and 2018

Socioeconomic risk markers of arthropod-borne virus (arbovirus) infections: a systematic literature review and meta-analysis

Temporal Evaluation of Insecticide Resistance in Populations of the Major Arboviral Vector Aedes Aegypti from Northern Nigeria

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