Factors associated to modification of first-line antiretroviral therapy due to adverse events in people living with HIV/AIDS

Azevedo, Larissa Negromonte; Ximenes, Ricardo Arraes de Alencar; Monteiro, Polyana; Montarroyos, Ulísses Ramos; Miranda-Filho, Demócrito de Barros

doi:10.1016/j.bjid.2019.11.002

Cited by 9 publications

(6 citation statements)

References 18 publications

(46 reference statements)

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“…The adverse event that has been occurred in greater than 40% of our study participants was anemia. Therefore, switching to other safer ART drugs like combination is very crucial [ 46 ]. Male study participants were more at high risk of developing anemia than female participants.…”

Section: Discussionmentioning

confidence: 99%

Magnitude and associated factors of anemia among AZT based HAART experienced adult HIV patients at University of Gondar Comprehensive Specialized Referral Hospital, Northwest, Ethiopia, 2019: a retrospective cohort study

et al. 2021

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Background Anemia is the most common hematologic abnormalities in AIDS patients usually associated with disease progression and poor clinical outcomes. Zidovudine (AZT), which is one of the nucleoside reverse transcriptase inhibitor drug families of the first line antiretroviral therapy regimen for HIV/AIDS patients, causes anemia due to early long-term of higher-dose therapy. This study was aimed to assess the magnitude and associated factors of anemia among AZT containing HAART experienced adult HIV/ADIS patients at University of Gondar Comprehensive Specialized Referral Hospital, northwest, Ethiopia, 2019. Methods A retrospective cohort study was conducted among a total of 320 adult AZT based HAART experienced HIV/AIDS patients from January 2016 to December 2018. Systematic random sampling technique was used to select the patients’ charts. All required data for this study were extracted from patients’ medical charts. Data were coded, cleared and entered into Epi Info version 3.5.3, and transformed to SPSS version 20 for analysis. Descriptive statistics, bivariable and multivariable logistic regression models were fitted to identify associated factors of anemia and P-value < 0.05 was considered as statistically significance. Results A total of 320 adult AZT based HAART experienced HIV/AIDS patients’ charts were assessed. Of the total patients, 198 (61.9%) were females and 133 (41.6%) were within the age range of 35–45 years. More than half, 237(76.9%) of the patients were from the urban area and 186 (58.1%) were on WHO clinical stage III at the baseline. The prevalence of anemia was 50% (95% CI 44.7–55.0%), 44.1% (95% CI 38.4–50.0%), 35.6% (95% CI 30.3–40.6%), 40% (95% CI 34.4–45.6%), 40.6% (95% CI 35.0–46.3) and 39.1% (95% CI 33.4–44.1%) at baseline, 6 months, 12 months, 18 months, 24 months and 30 months of follow-up period, respectively. The overall prevalence of anemia was 41.6%. Anemia had significant association with WHO clinical stage and base line Hgb values. Conclusions A significant number of participants were anemic in this study. WHO clinical stage and baseline Hgb value were the contributing factors for anemia among these patients. Therefore, anemia needs an immediate intervention on associated factor to improve the anemic status and living condition of HIV patient.

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Section: Discussionmentioning

confidence: 99%

Magnitude and associated factors of anemia among AZT based HAART experienced adult HIV patients at University of Gondar Comprehensive Specialized Referral Hospital, Northwest, Ethiopia, 2019: a retrospective cohort study

et al. 2021

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“…In the present study, the use of lamivudine and efavirenz, which are drugs with low renal toxicity, was related to death among patients that did not undergo dialysis. The literature points out that these drugs have adverse effects (dermatological, gastrointestinal symptoms and neuropsychiatric disorders) that may lead the patient to discontinue the treatment 30 . Consequently, these patients are more susceptible to opportunistic infections, hospitalization and death.…”

Section: Discussionmentioning

confidence: 99%

Death-related factors in HIV/AIDS patients undergoing hemodialysis in an intensive care unit

Cavalcante

Parente

Gomes

et al. 2021

Rev. Inst. Med. trop. S. Paulo

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“…Os achados epidemiológicos do presente estudo corroboram outros estudos realizados, onde a maior prevalência detectada é no gênero masculino (Azevedo, Ximenes, Monteiro, Montarroyos, & Miranda-Filho, 2020;Rodriguez, Torvisco, & Aceitero, 2019). Uma possível explicação para essa frequência maior em homens é o fato de o mesmo costumar ser visto pela…”

Section: Discussionunclassified

Importância do teste de genotipagem em pessoas vivendo com HIV no Estado do Pará, Brasil

Lima

Bentaberry-Rosa

Costa³

et al. 2021

RSD

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O presente estudo objetivou caracterizar o perfil clinico-epidemiológico de pessoas vivendo com HIV (PVHIV) residentes no estado do Pará. Foram incluídos todos os indivíduos, independente de idade ou sexo, cujas amostras, de 2013 a 2015, foram encaminhadas ao Laboratório Central do Pará (LACEN-PA) para a realização do teste de genotipagem do HIV. Os dados foram obtidos por meio da coleta de informações nos laudos do teste de genotipagem guardados no LACEN. Foram coletadas informações como sexo, idade, nível de escolaridade, raça, ano de diagnóstico, motivos relacionados a mudança de esquema terapêutico e presença de mutações. O gênero masculino foi predominante, com faixa etária entre 40 e 50 anos ou mais, pardos e com ensino fundamental. A maioria teve o diagnóstico para o HIV entre os anos 2000 e 2009, tendo a maior parte apresentado mudanças de esquema terapêutico. Tal fato se deu em grande parte pela presença de falha terapêutica e intolerância, corroborando assim com a presença de mutações. No presente estudo observamos um perfil epidemiológico de PVHIV condizente com a literatura, caracterizado pela prevalência do gênero masculino, com faixa etária entre 40 e 50 anos ou mais, pardo e escolaridade em nível fundamental. Foi possível observar também um alto índice de mudanças nos regimes terapêuticos, de falha terapêutica, além de elevadas taxas de mutações. Demonstrando assim, a importância do exame de genotipagem não só para a escolha da terapia mais adequada como também para a adoção de estratégias que busquem melhorar a adesão de PVHIV ao tratamento com antirretrovirais. Novos estudos que possam contribuir com a compreensão e identificação das mudanças dos regimes terapêuticos assim como a contribuição destes para o aparecimento de mutações e consequente falha terapêutica são necessários.

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Factors associated to modification of first-line antiretroviral therapy due to adverse events in people living with HIV/AIDS

Cited by 9 publications

References 18 publications

Magnitude and associated factors of anemia among AZT based HAART experienced adult HIV patients at University of Gondar Comprehensive Specialized Referral Hospital, Northwest, Ethiopia, 2019: a retrospective cohort study

Magnitude and associated factors of anemia among AZT based HAART experienced adult HIV patients at University of Gondar Comprehensive Specialized Referral Hospital, Northwest, Ethiopia, 2019: a retrospective cohort study

Death-related factors in HIV/AIDS patients undergoing hemodialysis in an intensive care unit

Importância do teste de genotipagem em pessoas vivendo com HIV no Estado do Pará, Brasil

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