Bacteremia due to Moraxella osloensis : a case report and literature review

Abstract

Herein we report the case of a 10-year-old boy with an autosomal mosaic mutation who developed bacteremia. The causative agent was identified as Moraxella osloensis by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and 16S rRNA gene sequencing. In the pediatric population, there have been 13 case reports of infection attributed to M. osloensis and this is the fifth reported case of pediatric bacteremia due to M. osloensis. After Moraxella species infection was confirmed, the patient recovered with appropriate antimicrobial therapy. It is important to consider that M. osloensis can cause serious infections, such as bacteremia, in otherwise healthy children.

Moraxella osloensis Bacteremia and Pneumonia in a Seventeen-Year-Old Patient

“…Moreover, while the more common Moraxella species (e.g., M. catarrhalis) are typically β-lactamase producing, this has been inconsistently reported among clinical M. osloensis isolates [5,6]. This uncertainty is illuminated by case reports showing sensitivities and effective treatment of this species in children with penicillin and ampicillin, which should not be effective in a β-lactamase producing organism [3,4]. Some reported cases, however, have required multiple trials of different antibiotics to achieve effective therapy.…”

“…M. osloensis has been isolated from environmental sources, and there have been few reports of the organism causing human disease in older and/or immunocompromised patients [3,4]. Among previously healthy children and adolescents, M. osloensis infection has been rarely reported.…”

Gut Microbiota Profiles in Early- and Late-Onset Colorectal Cancer: A Potential Diagnostic Biomarker in the Future

“…Moraxella osloensis showed a more significant difference in younger and older CRC patients (11 and 46%; p = 0.043, Fisher's exact test). M. osloensis, an anaerobic bacterium from healthy respiratory tract, is a rare pathogen found in immunocompromised patients such as cancer and organ recipients [82,83]. Some cases of M. osloensis infection in cancer include leukemia, melanoma, Hodgkin disease, breast, pancreas, and lung carcinoma [83,84].…”