Asthma exacerbation and viral infection in adult patients, Brazil

Silva, Raquel Cirlene; Couceiro, J. N. S. S.; Câmara, Fernando Portela; Valle, Solange; Santos, Norma

doi:10.1016/j.bjid.2015.03.004

Cited by 4 publications

(3 citation statements)

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“…Previous studies have reported that the severity of asthma exacerbations is significantly associated with viral respiratory infections 1920212223. Moreover, less responsiveness to beta 2 agonists has been reported in acute asthmatics with symptoms of viral respiratory infection 22. In contrast, another study has indicated that the presence of viral respiratory disease does not influence recovery from an asthma exacerbation in non-hospitalized patients 21.…”

Section: Discussionmentioning

confidence: 97%

“…Viral respiratory infections are obvious triggers for asthma exacerbations;31819 however, there is some controversy as to whether these viral infections affect the recovery time after an acute exacerbation of asthma. Previous studies have reported that the severity of asthma exacerbations is significantly associated with viral respiratory infections 1920212223. Moreover, less responsiveness to beta 2 agonists has been reported in acute asthmatics with symptoms of viral respiratory infection 22.…”

Section: Discussionmentioning

confidence: 99%

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Factors Affecting Recovery Time of Pulmonary Function in Hospitalized Patients With Acute Asthma Exacerbations

Kim

Lee

Kim

et al. 2016

Allergy Asthma Immunol Res

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PurposeProlonged recovery time of pulmonary function after an asthma exacerbation is a significant burden on asthmatics, and management of these patients needs to be improved. The aim of this study was to evaluate factors associated with a longer recovery time of pulmonary function among asthmatic patients hospitalized due to a severe asthma exacerbation.MethodsWe retrospectively reviewed the medical records of 89 patients who were admitted for the management of acute asthma exacerbations. The recovery time of pulmonary function was defined as the time from the date each patient initially received treatment for asthma exacerbations to the date the patient reached his or her previous best FEV1% value. We investigated the influence of various clinical and laboratory factors on the recovery time.ResultsThe median recovery time of the patients was 1.7 weeks. Multiple linear regression analysis revealed that using regular inhaled corticosteroids (ICS) before an acute exacerbation of asthma and concurrent with viral infection at admission were associated with the prolonged recovery time of pulmonary function.ConclusionsThe prolonged recovery time of pulmonary function after a severe asthma exacerbation was not shown to be directly associated with poor adherence to ICS. Therefore the results indicate that an unknown subtype of asthma may be associated with the prolonged recovery of pulmonary function time after an acute exacerbation of asthma despite regular ICS use. Further prospective studies to investigate factors affecting the recovery time of pulmonary function after an asthma exacerbation are warranted.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Factors Affecting Recovery Time of Pulmonary Function in Hospitalized Patients With Acute Asthma Exacerbations

Kim

Lee

Kim

et al. 2016

Allergy Asthma Immunol Res

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“…Indeed, chronic respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), have a multifactorial origin and are characterized by chronic inflammation of the airways that induces bronchial hyperresponsiveness and decreased lung function. In addition, infection with respiratory viruses including respiratory syncytial virus, rhinovirus or some coronaviruses (OC43, E229), induces significant physiological changes, mainly via the immune response, and may negatively impact patients' respiratory tract and lead to exacerbation 8,9 .…”

Section: Introductionmentioning

confidence: 99%

Are Patients with Asthma and Chronic Obstructive Pulmonary Disease Preferred Targets of COVID-19?

et al. 2021

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The coronavirus pandemic, known as coronavirus disease 2019 (COVID-19), is an infectious respiratory disease caused by SARS-CoV-2, a novel coronavirus first identified in patients from Wuhan, China. Since December 2019, SARS-CoV-2 spread swiftly around world and infected more than 25 million people and caused more than 800,000 deaths in 188 countries. Chronic respiratory diseases such as asthma and COPD appear to be a risk factor for COVID-19; however, their prevalence remains controversial. In fact, studies in China reported lower rates of chronic respiratory conditions in patients with COVID-19 than in the general population, while the trend is reversed in the United States and Europe. Although the underlying molecular mechanisms of a possible interaction between COVID-19 and chronic respiratory diseases remain unknown, some observations can help to resolve them. Indeed, physiological changes, immune response, or medication used against SARS-CoV-2 may have greater impact on patients with chronic respiratory conditions, already debilitated by chronic inflammation, dyspnea, and the use of immunosuppressant drugs like corticosteroids. In this review, we discuss the importance and the impact of COVID-19 on asthmatics and COPD patients, the possible available treatments, and patient management during the pandemic.

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Prevalence of viral respiratory infections amongst asthmatics: Results of a meta-regression analysis

Feddema

Claassen

2020

Respiratory Medicine

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Asthma exacerbation and viral infection in adult patients, Brazil

Cited by 4 publications

References 4 publications

Factors Affecting Recovery Time of Pulmonary Function in Hospitalized Patients With Acute Asthma Exacerbations

Factors Affecting Recovery Time of Pulmonary Function in Hospitalized Patients With Acute Asthma Exacerbations

Are Patients with Asthma and Chronic Obstructive Pulmonary Disease Preferred Targets of COVID-19?

Prevalence of viral respiratory infections amongst asthmatics: Results of a meta-regression analysis

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