Prevalence of viral respiratory infections amongst asthmatics: Results of a meta-regression analysis

Feddema, Jelle J.; Claassen, Eric

doi:10.1016/j.rmed.2020.106020

Cited by 22 publications

(18 citation statements)

References 78 publications

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“…However, our study also found that the positive rate of RHV was higher in inland areas. We hypothesized that RHV circulating in inland areas are not the same serotype and more virulent as those in coastal areas , which echoes with previous studies [14] that people infected with RHV were more likely to develop asthma in inland areas compared with those in temperate areas .…”

Section: Discussionsupporting

confidence: 70%

Epidemiology Characteristic and Co-infection Pattern of Pathogens in Patients With Respiratory Tract Infection in Southern China, 2018-2020.

Liang¹,

Wang²,

Liu³

et al. 2021

Preprint

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Background: Respiratory tract infections (RTIs) is the highest prevalent disease and southern china has a wide spectrum of respiratory pathogen. The aim of this work was to renew the epidemiology characteristics of respiratory pathogens found in children and adults with RTIs from 2018 to 2020 in southern China. Methods: In this work, a total of 134,552 nasopharyngeal or throat swabs (patients from 407 hospitals) were analyzed, and fourteen respiratory viruses (Influenza A virus, influenza B virus, parainfluenza viruses, respiratory syncytial virus, adenovirus, human rhinovirus, human metapneumovirus, human Coronavirus, human bocavirus, enterovirus, cytomegalovirus, herpes simplex virus, mycoplasma pneumoniae and chlamydia pneumoniae) were detected using PCR/RT-PCR. Result: The most common respiratory pathogens in southern china were ADV (16.19%), RSV (15.48%), RHV (11.51%), IAV (10.93%), MP (8.95%), EBV (8.70%), PIV (7.67%), IBV (5.44%), with IAV and ADV as the most prevalent pathogens in adults (11.68%) and children (17.10%) respectively. In detail, ADV (16.30%) and RSV (18.93%) are most common in 0-4 years old, with IAV (16.68%), ADV (20.36%) in 5-14 years old, with EBV (7.48%, 8.74%), IAV (15.43, 9.76%) in 15-49y, 50-64y and IAV (7.37%), IBV (2.43%) in 65-105y. Over three years witnessed an increase in PDR of PIV in 0-4y, 5-14y and 65-105y, and RHV in 5-14y and 15-49y. In month distribution, the positive detection rate of pathogens in adults were generally lower than that in children except for EBV and majority of pathogens has shown a sharp decline in 2020. In Upper RTIs, 77.27% (17/ 22) of co-infected patients had infection to ADV, with poly-infection to ADV and RHV the highest (8/22). In Lower RTIs, the ADV infected patients showed that its co-infection rate to MP, PIV, RHV or RSV were 19.51% (48/246), 15.45% (38/246), 14.63% (36/246) and 14.63% (36/246) respectively. Only IAV, IBV and EBV were detected in co-infection patients with lower RTIs. Conclusion: IAV and ADV were the most important respiratory pathogen in adults and children respectively in southern Chin and cross-reactivity might exist between ADV, RHV, PIV and MP. These should be taken into consideration when they formulate the strategies for co-infection avoidance in patients.

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Section: Discussionsupporting

confidence: 70%

Epidemiology Characteristic and Co-infection Pattern of Pathogens in Patients With Respiratory Tract Infection in Southern China, 2018-2020.

Liang¹,

Wang²,

Liu³

et al. 2021

Preprint

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“…In addition to the low frequency obtained in our study, our data suggest that infection with SARS-CoV-2 is not significantly associated with asthma exacerbation. Although it is known that viral respiratory infections can act as triggers for acute asthma exacerbations [2] only one of our patients had a moderate aggravation of the disease.…”

Section: Discussionmentioning

confidence: 70%

“…Viral infections are a very common cause of asthma exacerbation [1,2]. Rhinovirus, respiratory syncytial virus, influenza virus, human parainfluenza virus and metapneumovirus have been reported triggers of asthma aggravation [2], and almost one third of patients admitted for influenza suffered from asthma [3]. In light of these data, it would seem inevitable to identify asthma as a potential risk factor for COVID-19 [4].…”

Section: Introductionmentioning

confidence: 99%

Asthma prevalence in patients with SARS-CoV-2 infection detected by RT-PCR not requiring hospitalization

García-Pachón

Zamora-Molina

Soler-Sempere

et al. 2020

Respiratory Medicine

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The prevalence of asthma in patients hospitalized with SARS-CoV-2 has been studied and varies widely in the different series. However, the prevalence in SARS-infected patients not requiring hospitalization is not known. The objective of this study was to analyze the presence of asthma in a consecutive series of patients who tested positive in the RT-PCR assay for SARS-CoV-2 and did not require hospital admission. Methods and results: A total of 218 patients (58% of those who tested positive) did not require hospitalization; they had a median age of 45 years (IQR 34-57) and 57% were female. Six patients (2.8%) had a previous diagnosis of asthma. Only one patient developed a mild aggravation of asthma symptoms associated with SARS-CoV-2 infection. Conclusions: Few patients with asthma were infected by SARS-CoV-2, and this infection was not a significant cause of asthma exacerbation.

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“…RV is the leading cause of upper respiratory infections globally, affecting millions of people every year [6][7][8][9]. RV infections can be asymptomatic, cause mild upper respiratory tract symptoms or lead to severe lower respiratory tract infections and exacerbations in asthma and COPD [10,11].…”

Section: Virion Structure and Lifecyclementioning

confidence: 99%

Rhinovirus and Cell Death

Kerr

Mathew

Ghildyal

2021

Viruses

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Rhinoviruses (RVs) are the etiological agents of upper respiratory tract infections, particularly the common cold. Infections in the lower respiratory tract is shown to cause severe disease and exacerbations in asthma and COPD patients. Viruses being obligate parasites, hijack host cell pathways such as programmed cell death to suppress host antiviral responses and prolong viral replication and propagation. RVs are non-enveloped positive sense RNA viruses with a lifecycle fully contained within the cytoplasm. Despite decades of study, the details of how RVs exit the infected cell are still unclear. There are some diverse studies that suggest a possible role for programmed cell death. In this review, we aimed to consolidate current literature on the impact of RVs on cell death to inform future research on the topic. We searched peer reviewed English language literature in the past 21 years for studies on the interaction with and modulation of cell death pathways by RVs, placing it in the context of the broader knowledge of these interconnected pathways from other systems. Our review strongly suggests a role for necroptosis and/or autophagy in RV release, with the caveat that all the literature is based on RV-A and RV-B strains, with no studies to date examining the interaction of RV-C strains with cell death pathways.

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Prevalence of viral respiratory infections amongst asthmatics: Results of a meta-regression analysis

Cited by 22 publications

References 78 publications

Epidemiology Characteristic and Co-infection Pattern of Pathogens in Patients With Respiratory Tract Infection in Southern China, 2018-2020.

Epidemiology Characteristic and Co-infection Pattern of Pathogens in Patients With Respiratory Tract Infection in Southern China, 2018-2020.

Asthma prevalence in patients with SARS-CoV-2 infection detected by RT-PCR not requiring hospitalization

Rhinovirus and Cell Death

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