Factors Affecting Recovery Time of Pulmonary Function in Hospitalized Patients With Acute Asthma Exacerbations

Kim, Hyo Jung; Lee, Jaemoon; Kim, Jung Hyun; Park, So-Young; Kwon, Hyung Wook; Kim, Tae‐Bum; Moon, Hee Bom; Cho, You Sook

doi:10.4168/aair.2016.8.6.499

Cited by 4 publications

(4 citation statements)

References 24 publications

(45 reference statements)

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“…In our study, the CAP incidence in patients hospitalized with AEs was similar to a Korean (20.2%) study, 30 higher than the studies of Japanese (13.6%) 9 and Italian (7%) 11 populations, and lower than that found in Taiwan, China (30%) 13 . In contrast, the incidence of pneumonia in patients admitted to the intensive care unit (ICU) for severe AEs was only 16.8% in a multicenter retrospective cohort study in the United States 10 .…”

Section: Discussionsupporting

confidence: 89%

Development of a nomogram to estimate the risk of community‐acquired pneumonia in adults with acute asthma exacerbations

Duan,

Nafeisa,

Lian

et al. 2023

Clinical Respiratory J

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ObjectiveThe aim of this study is to investigate the clinical characteristics of acute asthma exacerbations (AEs) with community‐acquired pneumonia (CAP) in adults and establish a CAP prediction model for hospitalized patients with AEs.MethodsWe retrospectively collected clinical data from 308 patients admitted to Beijing Luhe Hospital, Capital Medical University, for AEs from December 2017 to August 2021. The patients were divided into CAP and non‐CAP groups based on whether they had CAP. We used the Lasso regression technique and multivariate logistic regression analysis to select optimal predictors. We then developed a predictive nomogram based on the optimal predictors. The bootstrap method was used for internal validation. We used the area under the receiver operating characteristic curve (AUC), calibration curve, and decision curve analysis (DCA) to assess the nomogram's discrimination, accuracy, and clinical practicability.ResultsThe prevalence of CAP was 21% (65/308) among 308 patients hospitalized for AEs. Independent predictors of CAP in patients hospitalized with an AE (P < 0.05) were C‐reactive protein > 10 mg/L, fibrinogen > 4 g/L, leukocytes > 10 × 109/L, fever, use of systemic corticosteroids before admission, and early‐onset asthma. The AUC of the nomogram was 0.813 (95% CI: 0.753–0.872). The concordance index of internal validation was 0.794. The calibration curve was satisfactorily consistent with the diagonal line. The DCA indicated that the nomogram provided a higher clinical net benefit when the threshold probability of patients was 3% to 89%.ConclusionsThe nomogram performed well in predicting the risk of CAP in hospitalized patients with AEs, thereby providing rapid guidance for clinical decision‐making.

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Section: Discussionsupporting

confidence: 89%

Development of a nomogram to estimate the risk of community‐acquired pneumonia in adults with acute asthma exacerbations

Duan,

Nafeisa,

Lian

et al. 2023

Clinical Respiratory J

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“…In detail, patients with a severe asthma exacerbation present a prolonged recovery period. The recovery time and the responsiveness to the treatment are variable here (18). A prolonged recovery may be associated with decreased prognosis and increased morbidity.…”

Section: Introductionmentioning

confidence: 99%

Do Current Asthma-Preventive Measures Appropriately Face the World Health Organization's Concerns: A Study Presentation of a New Clinical, Prospective, Multicentric Pediatric Asthma Exacerbation Cohort in Germany

et al. 2020

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In summer 2017, the World Health Organization published 10 facts on asthma, which is known as a major non-communicable disease of high clinical and scientific importance with currently several hundred million people—with many children among them—suffering from air passages inflammation and narrowing. Importantly, the World Health Organization sees asthma as being underdiagnosed and undertreated. Consequently, much more efforts in clinical disease management and research need to be spent on reducing the asthma-related health burden. Particularly, for young approximately 6 months aged patients presenting recurrent bronchitic respiratory symptoms, many parents anxiously ask the doctors for risk prognosis for their children's future life. Therefore, we urgently need to reevaluate if the current diagnostic and treatment measures are in concordance with our yet incomplete knowledge of pathomechanisms on exacerbation. To contribute to this increasing concern worldwide, we established a multicentric pediatric exacerbation study network, still recruiting acute exacerbated asthmatics (children >6 years) and preschool asthmatics/wheezers (children <6 years) since winter 2018 in Germany. The current study that has a currently population comprising 176 study participants aims to discover novel holistic entry points for achieving a better understanding of the poorly understood plasticity of involved molecular pathways and to define biomarkers enabling improved diagnostics and therapeutics. With this study description, we want to present the study design, population, and few ongoing experiments for novel biomarker research.Clinical Trial Registration: German Clinical Trials Register (Deutsches Register für Klinische Studien, DRKS): DRKS00015738.

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“…Most of the asthmatic patients have rare or intermittent exacerbations; however, there is evidence that a subset of asthmatics is ‘exacerbation-prone’ 18 Several epidemiologic studies have reported a strong correlation between FEV1 and the risk of asthma exacerbation. 19 20 21 Acute severe exacerbations in susceptible asthmatics activate pathways of inflammation and remodeling, resulting in the deterioration of lung function. Accelerated loss of lung function in turn increases the risk of exacerbation, resulting in a vicious cycle and the exacerbation-prone phenotype.…”

Section: Discussionmentioning

confidence: 99%

Effects of Immunoglobulin Replacement on Asthma Exacerbation in Adult Asthmatics with IgG Subclass Deficiency

Kim

Ban

et al. 2017

Allergy Asthma Immunol Res

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PurposeRecurrent respiratory tract infection is a common manifestation of primary immunodeficiency disease, and respiratory viruses or bacteria are important triggers of asthma exacerbations. Asthma often coexists with humoral immunodeficiency in adults, and some asthmatics with immunoglobulin (Ig) G subclass deficiency (IgGSCD) suffer from recurrent exacerbations. Although some studies suggest a benefit from Ig replacement, others have failed to support its use. This study aimed to assess the effect of Ig replacement on asthma exacerbation caused by respiratory infection as well as the asthma control status of adult asthmatics with IgGSCD.MethodsThis is a multi-center, open-label study of adult asthmatics with IgGSCD. All patients received monthly intravenous immunoglobulin (IVIG) for 6 months and were evaluated regarding asthma exacerbation related to infection, asthma control status, quality of life, and lung function before and after IVIG infusion.ResultsA total of 30 patients were enrolled, and 24 completed the study. Most of the patients had a moderate degree of asthma severity with partly (52%) or uncontrolled (41%) status at baseline. IVIG significantly reduced the proportion of patients with asthma exacerbations, lowered the number of respiratory infections, and improved asthma control status, compared to the baseline values (P<0.001). The mean asthma-specific quality of life and asthma control test scores were improved significantly (P=0.009 and P=0.053, respectively); however, there were no significant changes in lung function.ConclusionsIVIG reduced the frequency of asthma exacerbations and improved asthma control status in adult asthmatics with IgGSCD, suggesting that IVIG could be an effective treatment option in this population.

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Factors Affecting Recovery Time of Pulmonary Function in Hospitalized Patients With Acute Asthma Exacerbations

Cited by 4 publications

References 24 publications

Development of a nomogram to estimate the risk of community‐acquired pneumonia in adults with acute asthma exacerbations

Development of a nomogram to estimate the risk of community‐acquired pneumonia in adults with acute asthma exacerbations

Do Current Asthma-Preventive Measures Appropriately Face the World Health Organization's Concerns: A Study Presentation of a New Clinical, Prospective, Multicentric Pediatric Asthma Exacerbation Cohort in Germany

Effects of Immunoglobulin Replacement on Asthma Exacerbation in Adult Asthmatics with IgG Subclass Deficiency

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