Seroprevalence of hepatitis A immunity among children and adolescents in two cities of the Triângulo Mineiro region, state of Minas Gerais, Brazil

Gonçalves, Alana Arantes Santos; Oliveira, Luiz Carlos Marques de

doi:10.1016/j.bjid.2012.03.002

Cited by 3 publications

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“…In Brazil, seroprevalence studies conducted recently mainly in urban areas, showed a consistent decrease of the incidence rates in childhood 4,5,6,7,8,9,10 . Decrease in HAV circulation 8,9,11,12 as well as a progressive decline in fatal cases related to HAV infection in all Brazilian regions 8 have also begun to be noticed.…”

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Hepatitis A seroprevalence in public school children in Campos dos Goytacazes, Rio de Janeiro State, Brazil, prior to the introduction of the hepatitis A universal childhood vaccination

et al. 2016

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This cross-sectional study was carried out between August 2011 and July 2012 in the city of Campos dos Goytacazes in Rio de Janeiro State, Brazil. Dried blood spot samples were collected on filter paper from 919 individuals between the ages of 1 and 19 and were tested for antibodies against the hepatitis A virus (anti-HAV). The total prevalence was 20.7%, while 94.7% of children under the age of 5 were found to be susceptible to HAV infection. The prevalence of anti-HAV increased with age, reaching 33.3% among individuals aged between 15 and 19, thereby indicating that this municipality has a low level of endemicity for hepatitis A. Age, non-white skin color, accustomed to swimming in the river and more than five people living at home were the factors that were associated with an increase in the chance of a positive anti-HAV result. Mother's education level (secondary or tertiary) was considered a protective factor for HAV infection. The data obtained showed that a large proportion of the children from Campos dos Goytacazes were at risk of HAV infection, which should be minimized with the introduction of the vaccination program against hepatitis A that was launched in the municipality in 2011.

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confidence: 84%

Hepatitis A seroprevalence in public school children in Campos dos Goytacazes, Rio de Janeiro State, Brazil, prior to the introduction of the hepatitis A universal childhood vaccination

et al. 2016

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“…(FOCACCIA et al, 1998) De uma forma geral, praticamente todos os estudos sobre hepatite A que foram levantados mostraram associação com a idade, uma evidência provável do efeito coorte. (ALMEIDA et al, 2006;ASSIS et al, 2002;BRAGA et al, 2009;CERAN et al, 2012;CIACCIA et al, 2012;DOMINGUEZ et al, 2007;FOCACCIA et al, 1998;OLIVEIRA, 2012;GOMES et al, 2011;KOZLOMSKI et al, 2007;KREBS et al, 2011;KURY et al, 2016;MARKUS et al, 2011;PEREIRA et al, 2006;PINHEIRO et al, 2015;PINHO et al, 1998;SAHA et al, 2009;VITRAL et al, 2012;VITRAL et al, 2014;WONG et al, 2004;XIMENES et al, 2008;ZAGO-GOMES et al, 2005) Como verificado em outros estudos, (ALMEIDA et al, 2006;ASSIS et al, 2002;BRAGA et al, 2009;CERAN et al, 2012;CIACCIA et al, 2012;DOMINGUEZ et al, 2007;FOCACCIA et al, 1998;OLIVEIRA, 2012;GOMES et al, 2011;KOZLOMSKI et al, 2007;KREBS et al, 2011;KURY et al, 2016;MARKUS et al, 2011;PEREIRA et al, 2006;PINHEIRO et al, 2015;PINHO et al, 1998;SAHA et al, 2009;…”

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Inquérito soroepidemiológico sobre hepatites A e E em Cássia dos Coqueiros/SP, 2011 a 2013

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Hepatitis A and E seroprevalence and associated risk factors: a community-based cross-sectional survey in rural Amazonia

et al. 2014

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BackgroundHepatitis A virus (HAV) and hepatitis E virus (HEV) are both transmitted by the faecal-oral route, and represent common causes of acute hepatitis in developing countries. The endemicity of HAV infection has shifted from high to moderate in Brazil. Human cases of HEV infection seem to be rare, although the virus has been detected in swine livestock and effluents of slaughterhouses. This study was to determine the epidemiology of hepatitis A and E in one of the largest agricultural settlements in the Amazon Basin of Brazil.MethodsSerum samples collected from 397 individuals aged between 5 and 90 years during a population-based cross-sectional survey were tested for anti-HAV and anti-HEV antibodies. Associated risk factors and spatial clustering of HAV and HEV seropositivity were also analyzed.ResultsThe overall rate of HAV seropositivity was 82.9% (95% confidence interval (CI), 79.2-86.6%). Multilevel logistic regression analysis identified increasing age (in years; odds ratio (OR), 1.097; 95% CI, 1.050-1.147; P < 0.001) and crowding (OR, 1.603; 95% CI, 1.054-2.440; P = 0.028) as significant risk factors for HAV seropositivity. Anti-HEV IgG was detected in 50/388 settlers (12.9%, 95% CI, 9.5-16.2%). Anti-HEV IgM was detected in 7/43 (16.3%) anti-IgG positive samples, and 4 of them had a confirmed result by immunoblot. Increasing age was the only significant determinant of HEV seropositivity (OR, 1.033; 95% CI, 1.016-1.050; P < 0.001). No significant spatial clustering of HAV and HEV seropositivity was detected in the area.ConclusionsBoth HAV and HEV are endemic, with differing rates of infection in children and adults in this rural setting of the Brazilian Amazon. Anti-HEV prevalence was considerably higher than those previously reported in Brazil. The detection of HEV- specific IgM antibodies in four asymptomatic individuals is highly suggestive of the circulation of HEV in this rural population.Electronic supplementary materialThe online version of this article (doi:10.1186/1471-2334-14-458) contains supplementary material, which is available to authorized users.

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Seroprevalence of hepatitis A immunity among children and adolescents in two cities of the Triângulo Mineiro region, state of Minas Gerais, Brazil

Cited by 3 publications

References 5 publications

Hepatitis A seroprevalence in public school children in Campos dos Goytacazes, Rio de Janeiro State, Brazil, prior to the introduction of the hepatitis A universal childhood vaccination

Hepatitis A seroprevalence in public school children in Campos dos Goytacazes, Rio de Janeiro State, Brazil, prior to the introduction of the hepatitis A universal childhood vaccination

Inquérito soroepidemiológico sobre hepatites A e E em Cássia dos Coqueiros/SP, 2011 a 2013

Hepatitis A and E seroprevalence and associated risk factors: a community-based cross-sectional survey in rural Amazonia

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