Effects of standard ethanolic extract from Erythrina velutina in acute cerebral ischemia in mice

Rodrigues, Francisca; Sousa, Caren Nádia Soares de; Ximenes, Naiara Coelho; Almeida, Anália Barbosa; Cabral, Lucas Manoel da Silva; Patrocínio, Cláudio Felipe Vasconcelos; Silva, Aline Holanda; Leal, Luzia Kalyne Almeida Moreira; Júnior, José Eduardo Ribeiro Honório; Macedo, Danielle; Vasconcelos, Silvânia Maria Mendes

doi:10.1016/j.biopha.2017.11.093

Cited by 22 publications

(17 citation statements)

References 61 publications

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“…As there is a strong relationship between oxidative imbalance and pathophysiology of schizophrenia and Eryt extract has shown neuroprotective effect in previous studies, we decided to study oxidative and nitric compounds in several brain areas, such as PFC, HC and ST, related to the neurobiology of this mental disorder in animals submitted to the KET model of schizophrenia and treated with different doses of the standardized leaf extract of Eryt.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, a new alternative is proposed that contemplates the treatment of schizophrenia with the use of the compounds from Erythrina velutina , a common tree in the semiarid northeast of Brazil . It is traditionally used for treatment of psychotic disorders, since the trunk and its parts are loaded with alkaloids, terpenes and flavonoids, which promotes neuroprotective, anxiolytic, sedative, anticonvulsant, antinociceptive, antioxidant and anti‐inflammatory effects, from the neuromuscular blockade …”

Section: Introductionmentioning

confidence: 99%

“…In this regard, research on pharmacological actions with isolated plants or in combination with other substances has increased because they prove beneficial and curative effects in the human body and with fewer adverse effects . Erythrina sp.…”

Section: Introductionmentioning

confidence: 99%

“…Erythrina sp. (Fabaceae), for example, divided among different species, such as velutina , mulungu , caffra , variegata and abyssinica , acts not only in the CNS, but also has osteoprotectant, antibacterial and antineoplastic activity …”

Section: Introductionmentioning

confidence: 99%

“…[8] It is traditionally used for treatment of psychotic disorders, since the trunk and its parts are loaded with alkaloids, terpenes and flavonoids, which promotes neuroprotective, anxiolytic, sedative, anticonvulsant, antinociceptive, antioxidant and anti-inflammatory effects, from the neuromuscular blockade. [9,10] Some researches show positive results on the use of antioxidant and anti-inflammatory substances during the treatment of this disorder, since they participate in the reduction and prevention of oxidative damage present in the pathology of the disease, demonstrating a neuroprotective action. [2,[11][12][13] In this regard, research on pharmacological actions with isolated plants or in combination with other substances has increased because they prove beneficial and curative effects in the human body and with fewer adverse effects.…”

Section: Introductionmentioning

confidence: 99%

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Standardized extract of Erythrina velutina Willd. attenuates schizophrenia-Like behaviours and oxidative parameters in experimental animal models

Dias

Almeida

Vasconcelos

et al. 2018

Journal of Pharmacy and Pharmacology

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Objectives To study the effects of the standardized extract from the leaves of Erythrina velutina in behavioural and oxidative parameters in the ketamine‐induced schizophrenia model. Methods Mice received ketamine (KET) or saline for 7 days. From 8th to 14th day, the animals received Erythrine (Eryt) (100, 200 or 400 mg/kg) or olanzapine (Olanz), 1 h after KET administration. At 14th day, 30 min after the last administration of KET, the open‐field and pre‐pulse inhibition (PPI) tests were performed. Then, the animals were sacrificed and the prefrontal cortex (PFC), hippocampus (HC) and striatum (ST) were dissected for the oxidative tests. Key findings Ketamine increased spontaneous locomotor activity and grooming. KET decreased the PPI, which was reversed by combining it with Eryt or olanzapine. KET decreased GSH concentration in PFC and ST this was reversed by Eryt. KET increased MDA concentration in PFC and HC this was reversed by Eryt. Eryt and Olanzapine reduced MDA concentration in ST when compared to KET group. Nitrite concentration was reduced by administration of KET in the PFC. Conclusions These results demonstrate that the standardized extract of E. velutina can prevent behavioural symptoms and oxidative stress induced by repeated doses of KET.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Standardized extract of Erythrina velutina Willd. attenuates schizophrenia-Like behaviours and oxidative parameters in experimental animal models

Dias

Almeida

Vasconcelos

et al. 2018

Journal of Pharmacy and Pharmacology

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The variation in the levels of 18 amino acids in the cortex and plasma of cerebral ischemia C57BL/6 mice

Qiu

Jiang

et al. 2021

Biomedical Chromatography

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Emerging evidence suggests that amino acid (AA) neurotransmitters play important roles in the pathophysiological processes of cerebral ischemia. In this work, an HPLC with fluorescence detection (HPLC‐FLR) method was developed for the simultaneous determination of 18 AAs in the cortex and plasma after cerebral ischemia in mice. The ischemia model was prepared by bilateral common carotid artery occlusion, and then the cortex and plasma of the sham, ischemia, and naringenin groups were collected. Based on the protein precipitation method, a simple and effective sample preparation method was developed. The treated sample contained minimal proteins and lipids. The analysis of the sample was performed by the proposed HPLC‐FLR method in combination with o‐phthalaldehyde. The results showed a statistically significant increase in excitatory AAs (aspartic acid and glutamic acid), inhibitory AAs (glycine and 4‐aminobutyric acid), phenylalanine, citrulline, isoleucine, and leucine levels, and a decrease of glutathione and phenylalanine levels when compared with the sham group in the cortex. Besides, the administration of naringenin had significant effects on excitatory AAs, inhibitory AA (glycine), glutamine, tyrosine, phenylalanine, and leucine levels when compared with the sham group in the cortex. These findings could be utilized in studying and clarifying the mechanisms of ischemia.

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Determination of 23 related analytes in bone marrow fluid and hippocampus of C57BL/6 mice following cerebral ischemia–reperfusion injury by HPLC‐FLD

Zhang

Yang

Luo

et al. 2022

Biomedical Chromatography

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The study of brain diseases has long been of interest to researchers worldwide, and stroke is the third leading cause of death that threatens human health. At the same time, cerebral ischemia–reperfusion injury is closely associated with high rates of disability and mortality. The conditions of the 6‐aminoquinolyl N‐hydroxysccinimidyl carbamate method for the derivatization of amino acids in the bone marrow fluid and hippocampus of C57BL/6 mice with cerebral ischemia–reperfusion injury were explored and optimized, such as the column temperature, concentration of derivatization reagents and mobile phase concentration. The mobile phase consisted of 20 mm sodium acetate solution (phosphoric acid to adjust pH 5.0) and 60% acetonitrile solution at a flow rate of 1 ml min−1. The 23 analytes were separated and determined in a gradient elution procedure; the correlation coefficient r was >0.9990 in the range 0.1–8.0 μg ml−1. The results showed that the content of relevant analytes was significantly changed in the cerebral ischemia–reperfusion injury model, and the method was suitable for the simultaneous determination of 23 amino acids in the bone marrow fluid and hippocampus of C57BL/6 mice.

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Effects of standard ethanolic extract from Erythrina velutina in acute cerebral ischemia in mice

Cited by 22 publications

References 61 publications

Standardized extract of Erythrina velutina Willd. attenuates schizophrenia-Like behaviours and oxidative parameters in experimental animal models

Standardized extract of Erythrina velutina Willd. attenuates schizophrenia-Like behaviours and oxidative parameters in experimental animal models

The variation in the levels of 18 amino acids in the cortex and plasma of cerebral ischemia C57BL/6 mice

Determination of 23 related analytes in bone marrow fluid and hippocampus of C57BL/6 mice following cerebral ischemia–reperfusion injury by HPLC‐FLD

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