Granulomatous pigmented purpuric dermatosis: report of a Latin-American case with blaschkoid distribution

Carvajal, Daniela; Quiroz, Claudia; Morales, Claudia; Fernández, Javier D.

doi:10.1016/j.abd.2019.09.002

Cited by 10 publications

(4 citation statements)

References 6 publications

(12 reference statements)

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“…2 ). Notably, annular/comma-like vessels were more frequently seen in our study population (51.7%), compared with other studies which described that as twisted red loops, red circles and serpentine vessels 4 5 23 24 25 . We suggest that it was much easier to discriminate such vascular features from the diffuse red and brown patches in this study, attributing to high resolution image and polarization.…”

Section: Discussioncontrasting

confidence: 63%

Dermoscopic Findings and the Clinicopathologic Correlation of Pigmented Purpuric Dermatosis: A Retrospective Review of 60 Cases

Kim

Moon²,

Ryu

2021

Ann Dermatol

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Background Pigmented purpuric dermatosis (PPD) is known as a chronic recurrent eruption which usually presents with petechiae and pigmented macules on the lower extremities. Dermoscopy is a noninvasive diagnostic tool in identifying pigmented and vascular lesions, which can also be beneficial in the evaluation of PPD. Objective We aimed to analyze the common dermoscopic characteristics of PPD, and correlate those findings with the histopathologic features. Additionally, dermoscopic and pathological findings in this study population were compared with other similar studies from the literature review. Methods A retrospective analysis was performed using data of 60 patients who were diagnosed as PPD by skin biopsy and had dermoscopic examination. The pathologic analysis was performed by categorizing the pattern into lichenoid, perivascular, interface, and spongiotic subtype, and the dermoscopic assessment was performed by the three authors independently. Results In dermoscopy, 96.7% of the patients showed red globules and dots, followed by brownish patch, coppery-red pigmentation, and annular comma-like vessels. The pathologic pattern analysis revealed statistically significant association of lichenoid pattern with coppery red pigmentation, perivascular pattern with annular/comma-like vessels, and spongiosis pattern with reticular pigmented network and linear vessels. The interrater similarity test showed total kappa value of 0.811 which referred to “very good”. Conclusion In this study, the prevalence of dermoscopic features in Asian PPD patients was identified, which was similar with previous studies. The dermoscopic-pathologic correlation was found in four dermoscopic features. We suggest that dermoscopic examination is helpful in clinical diagnosis and pathological prediction of PPD.

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Section: Discussioncontrasting

confidence: 63%

Dermoscopic Findings and the Clinicopathologic Correlation of Pigmented Purpuric Dermatosis: A Retrospective Review of 60 Cases

Kim

Moon²,

Ryu

2021

Ann Dermatol

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“…In addition, autoimmune diseases are commonly associated with GPPD and were found in 20% of GPPD patients (9 of the 45 patients reported, shown in Table 1). The most common disease is hypothyroidism (44%), and other reported diseases include Sjogren's syndrome, multiple sclerosis, ulcerative colitis, and myasthenia gravis as in the present case [12,19,20,27,28]. Therefore, a thyroid function test may play a role in detecting hypothyroidism in a GPPD patient.…”

Section: Case Reports In Dermatologymentioning

confidence: 69%

Granulomatous Pigmented Purpuric Dermatosis in a Patient with (Inactive) Myasthenia Gravis: A Case Report and Review of the Literature

Dhekariyapak,

Wattanakrai

2023

Case Rep Dermatol

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Granulomatous pigmented purpuric dermatosis (GPPD) is a rare histologic variant of pigmented purpuric dermatosis (PPD) characterized by dermal histiocyte-rich interstitial infiltration with or without granuloma formation in addition to the other typical features of PPD. GPPD was previously observed more frequently to affect Asians and was reported to be associated with dyslipidemia. However, our literature search of 45 documented GPPD cases revealed an increasing prevalence in Caucasians in addition to dyslipidemia and associated autoimmune diseases. To date, etiopathogenesis of GPPD is unknown but may involve dyslipidemia, genetic and immunological factors such as autoimmune dysregulation or a sarcoidal reaction associated with <i>C. acnes</i>. GPPD is usually persistent and recalcitrant to treatments. We report a case of GPPD in a 57-year-old Thai woman with underlying myasthenia gravis who presented with a pruritic eruption on both lower legs. After treatment with 0.05% clobetasol propionate cream and oral colchicine, the lesion improved with marked flattening and disappeared with residual postinflammatory hyperpigmentation. We provide a literature review of the epidemiology, etiopathogenesis, concomitant comorbidities, clinical symptoms, dermatoscopic features, and treatments of GPPD.

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“…This variant has been associated with hyperlipidaemia, although this association is unclear and requires further investigation 2. Other frequent findings described are arterial hypertension and diabetes mellitus 2 5. The differential diagnosis of PPDs includes cutaneous vasculitis, stasis dermatitis, traumatic purpura and mycosis fungoides 1.…”

Section: Descriptionmentioning

confidence: 99%