Granulomatous pigmented purpuric dermatosis

Mendes, Sónia Raquel; Gameiro, Ana; Cardoso, José Carlos; Reis, José

doi:10.1136/bcr-2020-240052

Cited by 3 publications

(1 citation statement)

References 5 publications

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“…The granulomatous variant of PPD (GPPD) was first reported by Saito and Matsuoka in 1996 5 . Since then, only 40 cases of GPPD have been reported in the English literature 3,5‐30 . GPPD clinically presents as persistent, red to brown purpuric macules or papules, mostly involving the lower legs.…”

Section: Introductionmentioning

confidence: 99%

Granulomatous pigmented purpuric dermatosis: Clinical and histopathologic findings in a series of nine cases

2022

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We report the largest case series to date of granulomatous pigmented purpuric dermatosis (GPPD), a rare variant of pigmented purpuric dermatoses (PPD). GPPD can cause diagnostic difficulties as it can be mistaken clinically and histopathologically with numerous inflammatory and infectious dermatoses or even cutaneous T‐cell lymphoma. We compared the histopathological findings of nine cases of GPPD with a control group consisting of 10 randomly selected PPD of other subtypes. GPPD seems to predominantly affect the lower extremities of adult male patients; a clear association with hyperlipidemia or other systemic conditions could not be confirmed. Histopathologically, GPPD is characterized by a dermal histiocyte‐rich interstitial infiltrate with or without granuloma formation, thickened capillaries, extravasated erythrocytes, and/or hemosiderin deposits. In contrast to other forms of PPD, the inflammatory infiltrate of GPPD can extend to the mid or deep dermis and the admixed lymphocytic infiltrate is mainly composed of CD8+ T‐cells.

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Section: Introductionmentioning

confidence: 99%

Granulomatous pigmented purpuric dermatosis: Clinical and histopathologic findings in a series of nine cases

2022

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Granulomatous Pigmented Purpuric Dermatosis in a Patient with (Inactive) Myasthenia Gravis: A Case Report and Review of the Literature

Dhekariyapak,

Wattanakrai

2023

Case Rep Dermatol

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Granulomatous pigmented purpuric dermatosis (GPPD) is a rare histologic variant of pigmented purpuric dermatosis (PPD) characterized by dermal histiocyte-rich interstitial infiltration with or without granuloma formation in addition to the other typical features of PPD. GPPD was previously observed more frequently to affect Asians and was reported to be associated with dyslipidemia. However, our literature search of 45 documented GPPD cases revealed an increasing prevalence in Caucasians in addition to dyslipidemia and associated autoimmune diseases. To date, etiopathogenesis of GPPD is unknown but may involve dyslipidemia, genetic and immunological factors such as autoimmune dysregulation or a sarcoidal reaction associated with <i>C. acnes</i>. GPPD is usually persistent and recalcitrant to treatments. We report a case of GPPD in a 57-year-old Thai woman with underlying myasthenia gravis who presented with a pruritic eruption on both lower legs. After treatment with 0.05% clobetasol propionate cream and oral colchicine, the lesion improved with marked flattening and disappeared with residual postinflammatory hyperpigmentation. We provide a literature review of the epidemiology, etiopathogenesis, concomitant comorbidities, clinical symptoms, dermatoscopic features, and treatments of GPPD.

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Pigmented purpuric dermatoses: A review

Shekhar,

Eeshaan,

Tripathy

et al. 2024

Pigment International

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Pigmented purpuric dermatosis (PPD) comprises a group of skin conditions characterized by flat, nonpalpable petechiae and purpura as a result of capillaritis. Although the precise cause of PPD is as yet unknown, increased vascular permeability and capillary fragility are key factors in its pathophysiology. PPD has diverse clinical presentations, but the histopathology of all these variants essentially remains the same. The initial purpuric lesions develop a golden-brown hue owing to hemosiderin absorption and eventually progress to chronic pigmentary changes. These lesions, which often affect the lower limbs, are either asymptomatic or accompanied by moderate pruritus, and can be difficult to diagnose and treat. There are several subtypes of clinical presentations that have been documented over the years. In order to accurately diagnose PPD, a thorough clinical evaluation and, occasionally, a biopsy may be required. It is essential to identify the condition and reassure patients of its benign nature. Treatment is usually necessary due to the chronic nature of the condition, its consequences on physical and mental well-being, and the presence of significant lesions or itching. In this review, we outline the various prevalent PPDs and discuss their etiopathogenesis, clinical features, and diagnostic and treatment modalities.

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Granulomatous pigmented purpuric dermatosis

Cited by 3 publications

References 5 publications

Granulomatous pigmented purpuric dermatosis: Clinical and histopathologic findings in a series of nine cases

Granulomatous pigmented purpuric dermatosis: Clinical and histopathologic findings in a series of nine cases

Granulomatous Pigmented Purpuric Dermatosis in a Patient with (Inactive) Myasthenia Gravis: A Case Report and Review of the Literature

Pigmented purpuric dermatoses: A review

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