Synthesis optimization and characterization of chitosan-coated iron oxide nanoparticles produced for biomedical applications

Ünsoy, Gözde; Yalçın, Serap; Khodadust, Rouhollah; Gündüz, Güngör; Gündüz, Ufuk

doi:10.1007/s11051-012-0964-8

Cited by 280 publications

(130 citation statements)

References 45 publications

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“…Over the last decade, many reports have been focused on preparation CS-coated magnetic NPs [4,5]. The recent work concerns the CS modification leading to increase of amine group amount in polysaccharide chains [6].…”

Section: Introductionmentioning

confidence: 99%

Thermal stability of magnetic nanoparticles coated by blends of modified chitosan and poly(quaternary ammonium) salt

Ziegler-Borowska

Chełminiak

Kaczmarek

2014

J Therm Anal Calorim

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Magnetite nanoparticles (Fe 3 O 4 NPs) coated by modified chitosan (m-CS) rich of amino groups and its mixture with poly[N-benzyl-2-(methacryloxy)-N,N-dimethylethanaminium bromide] (PQ) with various mass ratios were prepared by co-precipitation method. The thermal stability of magnetic materials has been investigated by thermogravimetric analysis (TG/DTG/DTA) in air and nitrogen atmosphere. It was found that magnetic NPs coated by polymer blend were characterized by lower thermal stability than protected only by alone CS or m-CS. Magnetite NPs enhance thermooxidative degradation of polymers, however, the stable surface layer, formed from polymer degradation products, efficiently protects the magnetite transformation at higher temperatures. The content of magnetite in obtained systems has been also determined from TG curves.

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Section: Introductionmentioning

confidence: 99%

Thermal stability of magnetic nanoparticles coated by blends of modified chitosan and poly(quaternary ammonium) salt

Ziegler-Borowska

Chełminiak

Kaczmarek

2014

J Therm Anal Calorim

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“…Diantara beberapa metode pembuatan nanopartikel besi oksida, ko-presipitasi merupakan metode bottom up yang berpotensi karena dapat digunakan untuk menghasilkan nanopartikel dengan skala besar, murah, proses produksinya mudah, dan menghasilkan nanopartikel yang hidrofilik [3]. Fe3O4 merupakan besi oksida yang paling menjanjikan dan umum digunakan dalam aplikasi biomedis karena sifatnya yang biokompatibel [4], biodegradabel dan dapat dengan mudah dimodifikasi permukaannya [5].…”

Section: Pendahuluanunclassified

“…Kitosan dapat berinteraksi dengan muatan negatif (gugus hidroksil) yang ada di permukaan magnetik nanopartikel Fe3O4 [3]. Aspek penting dari kitosan sebagai pembawa obat yaitu kitosan dapat dihilangkan oleh renal clearance.…”

Section: Pendahuluanunclassified

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Preparation of Chitosan-Fe3O4 Nanoparticles by In-situ Co-Precipitation Using Tripolyphosphate / Citrate as Crosslinker and Characterization Using XRD

Mardila

Sabarudin

Santjojo

2016

Nat-B

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ABSTRAKNanopartikel kitosan-Fe3O4 telah disintesis secara one pot reaction dengan menggunakan kombinasi TPP:sitrat sebagai crosslinker. Metode yang digunakan yaitu ko-presipitasi in-situ garam besi dengan adanya kitosan dan crosslinker. Penelitian ini bertujuan untuk mengetahui pengaruh proses preparasi terhadap karakteristik nanopartikel kitosan-Fe3O4 yang dibuat pada beberapa kondisi yaitu rasio kitosan:Fe(II):Fe(III), rasio TPP:sitrat dan waktu crosslinking. Ukuran kristal nanopartikel hasil sintesis dihitung dengan menggunakan persamaan Debye Scherrer termodifikasi dengan nilai panjang gelombang, intensitas, 2θ, dan FWHM yang dihasilkan dari uji XRD. Ukuran kristal bare Fe3O4 dan nanopartikel kitosan-Fe3O4 masing-masing yaitu 6,22 nm dan 9,49 nm. Hasil analisis XRD menunjukkan bahwa pada nanopartikel hasil sintesis selain fasa Fe3O4 terdapat pula fasa γ-Fe2O3 yang diduga karena oksidasi Fe3O4. Ukuran kristal dan presentase Fe3O4 menurun dengan semakin banyaknya jumlah kitosan yang melapisi Fe3O4 dan semakin lamanya waktu crosslinking.Kata kunci: magnetik nanopartikel, kitosan-Fe3O4, in-situ, ko-presipitasi.

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“…Previous reports showed that a variety of active compounds such as kojic acid [19], doxorubicin [20,21], 5-aminosalicylic acid [22], 6-mercaptopurine [23], 10-hydroxycamptothecin [24], gallic acid [25,26], folic acid [27], arginine [28], and anthranilic acid [29] can be loaded onto the surface of magnetic nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Controlled-release formulation of perindopril erbumine loaded PEG-coated magnetite nanoparticles for biomedical applications

et al. 2014

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Iron oxide nanoparticles (FNPs) were synthesized due to low toxicity and their ability to immobilize biological materials on their surfaces by the coprecipitation of iron salts in ammonia hydroxide followed by coating it with polyethylene glycol (PEG) to minimize the aggregation of iron oxide nanoparticles and enhance the effect of nanoparticles for biological applications. Then, the FNPs-PEG was loaded with perindopril erbumine (PE), an antihypertensive compound to form a new nanocomposite (FPEGPE). Transmission electron microscopy results showed that there are no significant differences between the sizes of FNPs and FPEGPE nanocomposite. The existence of PEG-PE was supported by the FTIR and TGA analyses. The PE loading (10.3 %) and the release profiles from FPEGPE nanocomposite were estimated using ultraviolet-visible spectroscopy which showed that up to 60.8 and 83.1 % of the adsorbed drug was released in 4223 and 1231 min at pH 7.4 and 4.8, respectively. However, the release of PE was completed very fast from a physical mixture (FNPs-PEG-PE) after 5 and 7 min at pH 4.8 and 7.4, respectively, which reveals that the release of PE from the physical mixture is not in the sustained-release manner. Cytotoxicity study showed that free PE presented slightly higher toxicity than the FNPs and FPEGPE nanocomposite. Therefore, the decrease toxicity against mouse normal fibroblast (3T3) cell lines prospective of this nanocomposite together with controlled-release behavior provided evidence of the possible beneficial biological activities of this new nanocomposite for nanopharmaceutical applications for both oral and non-oral routes.

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Synthesis optimization and characterization of chitosan-coated iron oxide nanoparticles produced for biomedical applications

Cited by 280 publications

References 45 publications

Thermal stability of magnetic nanoparticles coated by blends of modified chitosan and poly(quaternary ammonium) salt

Thermal stability of magnetic nanoparticles coated by blends of modified chitosan and poly(quaternary ammonium) salt

Preparation of Chitosan-Fe3O4 Nanoparticles by In-situ Co-Precipitation Using Tripolyphosphate / Citrate as Crosslinker and Characterization Using XRD

Controlled-release formulation of perindopril erbumine loaded PEG-coated magnetite nanoparticles for biomedical applications

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