Controlled-release formulation of perindopril erbumine loaded PEG-coated magnetite nanoparticles for biomedical applications

Abstract

Iron oxide nanoparticles (FNPs) were synthesized due to low toxicity and their ability to immobilize biological materials on their surfaces by the coprecipitation of iron salts in ammonia hydroxide followed by coating it with polyethylene glycol (PEG) to minimize the aggregation of iron oxide nanoparticles and enhance the effect of nanoparticles for biological applications. Then, the FNPs-PEG was loaded with perindopril erbumine (PE), an antihypertensive compound to form a new nanocomposite (FPEGPE). Transmission electron microscopy results showed that there are no significant differences between the sizes of FNPs and FPEGPE nanocomposite. The existence of PEG-PE was supported by the FTIR and TGA analyses. The PE loading (10.3 %) and the release profiles from FPEGPE nanocomposite were estimated using ultraviolet-visible spectroscopy which showed that up to 60.8 and 83.1 % of the adsorbed drug was released in 4223 and 1231 min at pH 7.4 and 4.8, respectively. However, the release of PE was completed very fast from a physical mixture (FNPs-PEG-PE) after 5 and 7 min at pH 4.8 and 7.4, respectively, which reveals that the release of PE from the physical mixture is not in the sustained-release manner. Cytotoxicity study showed that free PE presented slightly higher toxicity than the FNPs and FPEGPE nanocomposite. Therefore, the decrease toxicity against mouse normal fibroblast (3T3) cell lines prospective of this nanocomposite together with controlled-release behavior provided evidence of the possible beneficial biological activities of this new nanocomposite for nanopharmaceutical applications for both oral and non-oral routes.

Superparamagnetic iron oxide nanoparticles dispersed in Pluronic F127 hydrogel: potential uses in topical applications

“…11,17 Regarding the addition of an extra non-magnetic layer of MSA on Fe 3 O 4 NPs surface, a decrease in the M s value was observed. 5,55,56 This value is lower than the value observed for Fe 3 O 4 as-synthesized nanoparticles ($75 emu g À1 ).…”

<p>Synthesis and properties of magnetic nanotheranostics coated with polyethylene glycol/5-fluorouracil/layered double hydroxide</p>

“…30 Pure PEG is represented by two main diffraction peaks of high intensity at 19.3° and 23.50° (Figure 1F). 34,58 The characteristic peak of 5-FU appeared at 28.44° (Figure 1G). 59 The XRD peaks of core-shell nanoparticles with MLDH and ZLDH nanocarriers are presented in Figure 1A and B, respectively.…”

Multifunctional Platforms Based on Graphene Oxide and Natural Products

“…To study the controlled release of the loaded biological active agent (BAA) onto graphene oxide, a phosphate buffer solution with a pH of 7.4 was used. Various studies showed that anions such as HPO42− and H2PO4− influence the controlled release of drugs [54,55]. The release rate of the BAA was measured by adding 65 mg GO-BAA into 25 mL of phosphate buffer solution (pH = 7.4).…”