1,2,4-Triazoloazine derivatives as a new type of herpes simplex virus inhibitors

Synthesis, characterization and in vitro cytotoxicity of three types of platinum(II) complexes containing 5,7-diethyl-1,2,4-triazolo[1,5-a]pyrimidine

“…Compared with purines, the fused-ring system of these ligands differs only in the presence of a pyrimidine nitrogen atom in a bridgehead position and the disappearance of the acidic H-proton of the five-membered ring [6,7]. Furthermore, these bicyclic heterocycles have been subjected to chemical and biological tests due to their pharmacological properties, including anticancer [8,9], antibacterial [10], antiviral [11], anti-inflammatory [12,13], fungicidal [14], antiparasitic [15][16][17][18][19] and leishmanicidal properties [20][21][22][23][24].…”

Recent Advances in 1,2,4‐Triazole Scaffolds as Antiviral Agents

“…Presumably, their mechanism of action is assumed by the blocking of DNA dependent DNA polymerase, a key enzyme of viral replication. [101,102]…”

Fluorinated [1,2,4]triazolo[1,5-a]pyrimidines and [1,2,4]triazolo[5,1-c][1,2,4]triazines*

“…This could be probably due to the electronwithdrawing effect of the triazine nitrogen atom N-5, which shifts the fluorine peak downfield. An attempt to obtain compounds 8a,c from hydrazones 7a,c by heating in pyridine at reflux [18] led to the product of two reactions, namely, nucleophilic substitution of the fluorine atom and cyclization, to Zwitter-ions 9a,c were also obtained by counter synthesis, namely, by the reaction of triazolyldiazonium salts 6a,c prepared by the diazotization of 3-aminotriazoles 4a,c with the diethyl pyridinium malonate bromide (10) in the presence of pyridine.…”

“…In the present work, we continued a study of the feasibility of structural modification of fluorouracil and investigated the synthesis of [1,2,4]triazolo[1,5-a]pyrimidines and [1,2,4]triazolo [5,1-c][1, 2,4]triazines. Some of these compounds have significant antiviral activity [17,18] and may be seen as structural analogs of both pyrimidines and purines.…”