06 / Screening for Sexual Health Infections Including Chlamydia, Gonorrhea and Syphilis in Accordance With European Aids Clinical Society (Eacs) Guidelines

Kerr, Colm; Allen, Niamh; Moynan, David

doi:10.26226/morressier.5af060641dd164001d5ef4a4

Cited by 2 publications

(1 citation statement)

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“…The most frequently detected mutations in ART-NP were K103NS, which confers high-level resistance to NVP and EFV, M41L, which reduces susceptibility to TDF and ABC when in combination with other NRTIs mutations, and M184VI, which causes high-level resistance to recommended first line drugs 3TC and FTC [22]. L90M was the resistance mutation to PIs with the highest prevalence, and it causes reduced susceptibility to ATV and LPV.…”

Section: Discussionmentioning

confidence: 99%

Increasing Prevalence of HIV-1 Transmitted Drug Resistance in Portugal: Implications for First Line Treatment Recommendations

Pingarilho

Pimentel

Diogo³

et al. 2020

Viruses

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Introduction: Treatment for All recommendations have allowed access to antiretroviral (ARV) treatment for an increasing number of patients. This minimizes the transmission of infection but can potentiate the risk of transmitted (TDR) and acquired drug resistance (ADR). Objective: To study the trends of TDR and ADR in patients followed up in Portuguese hospitals between 2001 and 2017. Methods: In total, 11,911 patients of the Portuguese REGA database were included. TDR was defined as the presence of one or more surveillance drug resistance mutation according to the WHO surveillance list. Genotypic resistance to ARV was evaluated with Stanford HIVdb v7.0. Patterns of TDR, ADR and the prevalence of mutations over time were analyzed using logistic regression. Results and Discussion: The prevalence of TDR increased from 7.9% in 2003 to 13.1% in 2017 (p < 0.001). This was due to a significant increase in both resistance to nucleotide reverse transcriptase inhibitors (NRTIs) and non-nucleotide reverse transcriptase inhibitors (NNRTIs), from 5.6% to 6.7% (p = 0.002) and 2.9% to 8.9% (p < 0.001), respectively. TDR was associated with infection with subtype B, and with lower viral load levels (p < 0.05). The prevalence of ADR declined from 86.6% in 2001 to 51.0% in 2017 (p < 0.001), caused by decreasing drug resistance to all antiretroviral (ARV) classes (p < 0.001). Conclusions: While ADR has been decreasing since 2001, TDR has been increasing, reaching a value of 13.1% by the end of 2017. It is urgently necessary to develop public health programs to monitor the levels and patterns of TDR in newly diagnosed patients.

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Section: Discussionmentioning

confidence: 99%

Increasing Prevalence of HIV-1 Transmitted Drug Resistance in Portugal: Implications for First Line Treatment Recommendations

Pingarilho

Pimentel

Diogo³

et al. 2020

Viruses

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Clinical manifestations, diagnosis and treatment of HIV infection of stage 4 (severely symptomatic stage) in the practice of a health professional

Nikitina

Rusanova

Zhilenkova

2020

Terapevt (General Physician)

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HIV infection is a significant problem in the modern world, because there are more and more infected people every year. This article will consider: the clinical picture, diagnosis and treatment of this disease in different countries. Based on these data, the following conclusions will be made to help doctors in their future practice correctly approach the diagnosis and treatment of patients with this disease.

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06 / Screening for Sexual Health Infections Including Chlamydia, Gonorrhea and Syphilis in Accordance With European Aids Clinical Society (Eacs) Guidelines

Abstract: This audit aims to assess the rates of baseline nucleic acid amplification testing (NAAT) for chlamydia and gonorrhoea infection and serum syphilis testing among newly attending HIVinfected persons at the HIV clinic of St James's Hospital, Dublin.

Cited by 2 publications

References 1 publication

Increasing Prevalence of HIV-1 Transmitted Drug Resistance in Portugal: Implications for First Line Treatment Recommendations

Increasing Prevalence of HIV-1 Transmitted Drug Resistance in Portugal: Implications for First Line Treatment Recommendations

Clinical manifestations, diagnosis and treatment of HIV infection of stage 4 (severely symptomatic stage) in the practice of a health professional

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