This study aimed to investigate the anti-inflammatory activities of raw (P) and roasted (RP) Perilla frutescens Britton (perilla) seeds in RAW 264.7 macrophages and an ulcerative colitis mouse model. In lipopolysaccharide-treated RAW 264.7 cells, treatment with ethanol extract of P at the concentrations of 75 and 150 µg/mL decreased nitric oxide (NO), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) levels to 48-85% of the control (p<0.01). Treatment with RP extract exhibited similar effects on NO, IL-6, and TNF-α, decreasing those levels to 51-84% of the control (p<0.01). In dextran sulfate sodium-treated ulcerative colitis mice, dietary treatment with 1% RP for 7 days decreased the colonic levels of prostaglandin E 2 and leukotriene B 4 to 34% and 58% of the control, respectively (p<0.05). Dietary P treatment, however, did not decrease those levels significantly. These results indicate that roasted perilla seed exerts anti-inflammatory activity both in vitro and in vivo.
The purpose of this study was to explore teachers' workload and its sources from teachers' perspective. Toward the purpose, interviews with and essays written by teachers were analyzed to interpret the meaning of teachers' workload and examine the relationship between their workload and social forces. The results indicated that teachers' workload could be fully understood when amount, intensity and nature of teachers' work were considered together. Among them the nature of work centered on non-educational affairs was perceived most serious problem by the teachers. However, most of the teachers felt helpless at their situation largely made by socio-structural factors including neoliberalism, bureaucracy and authoritarianism. Such a submissive reaction of teachers interacted with the forces to contribute to sustain their predicament.
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