The objective of this study was to examine the ability of extracts from Phellinus linteus (PL) and rice with Phellinus linteus mycelium (PLM) to inhibit obesity and diabetes. The efficacy of PL and PLM were evaluated using Oil Red O staining, cholesteryl ester transfer protein (CETP) levels, protein tyrosine phosphate 1B (PTP1B) levels, organ weight, and serum lipid levels. Lipid accumulation significantly decreased by 76% and 59% upon treatment with 300 μg/mL of PL and PLM, respectively (P<0.01). The inhibition of CETP activity increased 99% upon treatment with 300 μg/mL of PL or PLM. Treatment with 3, 10, 30, 100, and 300 μg/mL of PL, changed PTP1B activity by 10, 11, 14, 12, and 18% respectively. Also, treatment with increasing concentrations of PLM led to a significant concentration-dependent inhibition of PTP1B activity (P<0.01). PL and PLM were orally administered for 28 days after a high fat diet (HFD). PL significantly (P<0.05) reduced triglyceride and cholesterol levels. In addition, PLM significantly (P<0.05) reduced triglyceride, cholesterol, and HDL-cholesterol levels. GOT and GPT were not significantly affected. These results indicate that PL and PLM extracts have potent and useful activities for the treatment of obesity and diabetes mellitus.

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-A robust new algorithm for R wave detection named for Multiscale-based Peak Detection(MSPD) is assessed in this paper using MIT/BIH Arrhythmia Database. MSPD algorithm is based on a matrix composed of local maximum and find R peaks using result of standard deviation in the matrix. Furthermore, By reducing needless procedure of proposed algorithm, improve algorithm ability to detect R peak efficiently. And algorithm performance is assessed according to detection rates about various arrhythmia database.

ÖZETGPS sisteminin jeodezik çalışmalarda kullanımı, gün geçtikçe yaygınlaşmakta ve bu sistem adım adım haritacılık sektöründe zirveye tırmanmaktadır. Faz ölçüleri kullanmak suretiyle mm mertebesinde duyarlık elde edilmesi, her türlü hava koşullarında gözlem yapılması, noktaların birbirlerini görme şartı olmaması ise tercih unsurunu artırmaktadır. Ayrıca, her geçen gün ölçü tekniklerinin geliştirilmesi, deformasyon ölçmeleri, fay hareketlerinin izlenmesi, duyarlı jeoid haritalarının çıkarılması, halihazır harita yapımı vb. çalışmalarda GPS'in kullanımını yaygınlaştırmıştır.Anahtar Kelimeler : Global konum belirleme sistemi, Jeodezi, Haritacılık GLOBAL POSITIONING SYSTEM (GPS) ABSTRACTUse of GPS is becoming more widespread on surveying engineering. Especially, preference to GPS is increased by getting accuracy of order of milimeter, making observation on every weather forecast, without requiring intervisibility between station. Besides, developing new observation techniques and technologies in GPS increased its use in deformation measurements, monitoring crustal movements, mapping precise geoid maps, detail surveying, etc.

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