The transpulmonary thermodilution technique (TPTD) is a multi-parametric advanced cardiopulmonary monitoring technique that provides important parameters required for making decisions in critically ill patients. The TPTD measures cardiac output (CO) , global end-diastolic volume (GEDV) , and intra-thoracic blood volume (ITBV) , which are more reliable volumetric parameters of preload than filling pressures etc CVP, PAOP. Extravascular lung water (EVLW) is one of the most important parameters obtained by TPTD. The EVLW is an accurate quantitative parameter for pulmonary edema, the best pulmonary specific index of disease severity in patients with ARDS. Pulmonary vascular permeability (PVPI) is the ratio between EVLW and pulmonary blood volume, which indicates vascular wall damage. PVPI enables differentiation between cardiogenic (hydrostatic pulmonary edema) and non-cardiogenic (increased vascular permeability) pulmonary edema.
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