A novel series of the benzimidazole or benzothiazole phenyl ester derivatives of ursolic acid 4a~4h were prepared via ursolic acid, substituted benzaldehyde, and o-phenylendiamine or 2-aminothiophenol. The compounds were structurally confirmed by 1 等生物活性, 且毒副作用较小. 但其脂溶性和水溶性均 比较差, 不易透过生物膜, 故与同类临床药物相比其药 效明显偏低 [6] . 鉴于此, 本文以熊果酸为先导物, 进行 结构修饰, 将具有良好抗炎、抗癌、抗菌等药理活
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