Synthesis and Anti-inflammatory Activity of Novel Benzimidazole (Benzothiazole) Phenylursolate

Abstract

A novel series of the benzimidazole or benzothiazole phenyl ester derivatives of ursolic acid 4a～4h were prepared via ursolic acid, substituted benzaldehyde, and o-phenylendiamine or 2-aminothiophenol. The compounds were structurally confirmed by 1 等生物活性, 且毒副作用较小. 但其脂溶性和水溶性均 比较差, 不易透过生物膜, 故与同类临床药物相比其药 效明显偏低 [6] . 鉴于此, 本文以熊果酸为先导物, 进行 结构修饰, 将具有良好抗炎、抗癌、抗菌等药理活

Novel Fluorescence Probe for Fe3+and Application of Imaging in Living Cells

“…罗丹明类衍生物具有优异的光化学和光物理性能, 如摩尔消光系数高、光稳定性好、荧光量子产率高、相 对较长的激发和发射波长(＞500 nm)、对 pH 不敏感等, 使其成为了制备荧光探针的一种理想材料 [19～21] . 基于 罗丹明的螺酰胺环"off-on"机理 [22,23] …”

Synthesis and Antifungal Activity of Novel 2-(1H-Benzimidazol-2-yl)-5-substituted-1,3,4-oxadiazole Derivatives

“…因此, 研制新型、高效的苯并 咪唑杀菌剂以克服或降低病原菌的抗药性十分必要. 另一方面, 1,3,4-噁二唑类化合物也有很重要的生 物活性, 包括抗炎 [9] 、抗癌 [10] 、抗病毒 [11] 、抑菌 [12,13] .…”