From 5 weeks of age, stroke-prone spontaneously hypertensive rats (SHRSP) were fed a diet based on Chlorella (Chlorella vulgaris E-25) and were either observed until natural death or sacrificed at 29 weeks of age in order to examine the effects of the alga on blood pressure, incidence of stroke lesions, hypertensive vascular lesions and life-span.The results were as follows: 1) Elevation of blood pressure was depressed from the start of Chlorella feeding, and after 10 weeks of age the blood pressure remained unchanged at 210 to 230mmHg.2) The average life-span of the Chlorella diet group was remarkably longer than that of the control group. 3) In the Chlorella diet group, depression of plasma renin activity (PRA), reduction of incidence of cerebral stroke lesions, lowering of incidence of hypertensive vascular lesions in the kidneys, testes and adrenals, and depression of decrease in the elastin content in the aorta were recognized. This group also showed fewer changes in electron microscopical findings in the mesenteric arteries.These results demonstrated that the PRA of SHRSP fed the Chlorella diet was just as low as that of normotensive rats (WKY), and that the effects resulted in the inhibition of vascular lesions, and lowering of the incidence of cerebral stroke lesions, thus extending the life-span.
Stroke-prone spontaneously hypertensive rats (SHRSP) were fed a diet based on Euglena dry cells (Euglena gracilis z) as a protein source from 5 weeks of age, and observed until natural death or sacrifice at 35 weeks of age in order to examine the effects of the diet on blood pressure, incidence of cerebral stroke lesions and life-span.The results were as follows : (1) The Euglena diet had no significant effect on blood pressure, but obvious prolongation of life-span was observed. The incidence of cerebral stroke and hypertensive vascular lesions was somewhat lower than in control rats. (2) In the Euglena diet group sacrificed at 35 weeks of age, a reduced incidence of cerebral stroke lesions, a lower incidence hypertensive vascular lesions in the kidneys, testes and adrenals, suppressed elevation of plasma renin activity (PRA), and a less marked decrease in the elastin content of the aorta were recognized.Moreover, this group showed fewer changes in electron microscopical findings in the mesenteric arteries.(3) The lipid peroxide level (TBARS value) in the serum of the control group showed an increase after 15 weeks of age when cerebral vascular lesions began to develop, but that in the Euglena diet group remained almost unchanged.These results suggest that the effect of a Euglena diet in prolonging the life-span of SHRSP might be due to delayed aging or destruction of elastic fibers of the aorta.
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