MR imaging of cerebral lesions accompanying stroke in stroke-prone spontaneously hypertensive rats.

Prediction of Stroke Lesions in Stroke-prone Spontaneously Hypertensive Rats by Glutathione Peroxidase in Erythrocytes

“…Tomita et al 6 ) have studied the incidence of cerebral strokes and the change in lipid peroxide level in blood of SHRSP, and suggested that a sudden elevation of the lipid peroxide level in blood just before the incidence of a stroke was a factor for inducing the stroke. Takahashi et al 17) have recently studied magnetic resonance imaging (MRI) in relation to pathological findings in SHRSP during cerebral strokes, and reported that the time-course change due to the incidence of a cerebral stroke in SHRSP could be detected and identified noninvasively by MRI. The present authors 9 ,10) have found in previous studies on the relationship between improving proteinous nutrients from the progressive stage of hypertension and preventing cerebrovascular lesions that the GSH-Px activity in erythrocytes dropped slightly prior to the elevation of serum lipid peroxide level.…”