This study was carried out to determine the effect of mature date kernel powder on males of white mice weighing 150-200 g. Rats were divided into eight groups (two for control "-" groups) and two control (+) groups inflicted with hypercholesterolemia and diabetes mellitus were fed on the basal diet with germinated powdered dates stones 5%, and two groups also infected with hypercholesterolemia and high blood sugar are fed basal feed with extracts from dates soaked in methanol, dried and added to distilled water after methanol volatilization are administered orally lat 1/2 ml level daily . High cholesterol in serum of male rats caused by feeding them on the standard diet containing 1.5% cholesterol plus 10% fat from sheep tail for 15 days according to Ain (1993).Diabetic rats were previously injected with alloxan at 150 mg / kg body weight into the peritoneal membrane according to method described by Desai and Bhide (1985).At the end of the experiment (28 days) body weight gain (BWG), feed intake (FI) and feed efficiency ratio (FER) calculated and the blood samples, were taken from ventricular vein to serum separate for biochemical analysis. Slaughtering carried out for rats after 12 hours of fasting under anesthesia. Blood samples were taken in dry tubes and left to coagulate at room temperature, then centrifuged for 10 min at 3000 rpm to separate the serum. The serum was aspirated