التأثير المحتمل الخافض للکوليسترول لبعض الغرويات النباتية والحيوانية باستخدام ذکور فئران الألبينو

Abstract

This investigation was conduced to explore the protective effect of Carob seeds , Arabic gum were used at 500 mg/kg body weight in diet for 42 days as hypercholesterolemic agent to improve the blood glucose level , the lipids profile (Triglycerides(TG)-T.C-LDL-HDL-VLDL) , in addition ,the oxidants (MDA) and antioxidants enzymes activities including SOD, GSH , CAT& GPX. Twenty five(25) male nature albino rats weighting between 180 ± 200 g were used , divided to five main groubs ,(5 rats in each group), one of them used as control-ve while other groups had given 1.5% cholesterol plus 10% sheep tail for 15 days as a positive group. One of these group left as control+ve and other groups with orally administration of carob seed powder , carob seeds extract, arabic gum at doses of 500 mg /kg B. W. T , respectively for 42 days. Such treatments lowerd the TC,TG,VLDL,LDL,& AI, While raised the HDL, Also colloids diets reduced serum glucose while Triglycerides (TG) ,HDL increased, the antioxidant enzymes (SOD,CAT ,GPX,GSH) also ,increased.These treatments improved also; the histopatholgical changes due to hypercholesterolemia; being in line with the biochemical changed moreover,Therefore, the study recommends that the colloids can be used in the treatment of the hypercholesterolemic, the family food, should tend to envent food with colloids, specially the carob powder and carob extract, that easily (can be) added to baking goods ,similarly arabic gum many be blended with foods.