Elenagen is a plasmid encoding p62/SQSTM1, the first DNA vaccine possessing two mutually complementing mechanisms of action: it elicits immune response against p62 and mitigates systemic chronic inflammation. Previously, Elenagen demonstrated anti-tumor efficacy and safety in rodent tumor models and spontaneous tumors in dogs. This multicenter I/IIa trial evaluated safety and clinical activity of Elenagen in patients with advanced solid tumors. Fifteen patients were treated with escalating doses of Elenagen (1- 5 mg per doses, 5 times weekly) and additional 12 patients received 1 mg dose. Ten patients with breast and ovary cancers that progressed after Elenagen were then treated with conventional chemotherapy. Adverse events (AE) were of Grade 1; no severe AE were observed. Cumulatively twelve patients (44%) with breast, ovary, lung, renal cancer and melanoma achieved stable disease for at least 8 wks, with 4 of them (15%) had tumor control for more than 24 wks, with a maximum of 32 wks. The patients with breast and ovary cancers achieved additional tumor stabilization for 12-28 wks when treated with chemotherapy following Elenagen treatment. Therefore, Elenagen demonstrated good safety profile and antitumor activity in advanced solid tumors. Especially encouraging is its ability to restore tumor sensitivity to chemotherapy.
The definition of the concept of "readiness of practical psychologists for activities on a professional group development" is given as a complex formation, which is manifested in developed professional knowledge and competence in the organizational psychology and ability to perform psychological education of the leader and the members of the group, psychological motivation for the professional development and professional activities of each member of the group, psychological support for the professional group development.The scientific approaches to the content of the psychologists' training are generalized, in particular, the specific features of practical psychologists' training are distinguished. The special aspects of psychologists' activities in the field of organizational psychology are characterized. The structure of the readiness of practical psychologists for the professional activities in the organization is defined. The components of readiness of practical psychologists for the activities in the field of organizational psychology in general and, in particular, for the group development are characterized, namely, motivational, cognitive, operational and technological, communicative, reflexive. The special role of the communicative component of the readiness of practical psychologists for the activities with a professional group is proved, which is manifested in the commitment of the future psychologist to communication and actualization of altruistic orientation and a high level of empathy; intellectual abilities allowing to have an effective communication; social facilitation, i.e. ability of the psychologist to influence the subjects.
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