©Î. Ì. Îëåùóê, ß. ². ²âàíê³â ÄÂÍÇ Òåðíîï³ëüñüêèé äåðaeàâíèé ìåäè÷íèé óí³âåðñèòåò ³ìåí³ ². ß. Ãîðáà÷åâñüêîãî ÌÅËÀÒÎÍ²Í ßÊ ÃÅÏÀÒÎÏÐÎÒÅÊÒÎÐ ÏÐÈ ÖÓÊÐÎÂÎÌÓ Ä²ÀÁÅÒ²ÌÅËÀÒÎÍ²Í ßÊ ÃÅÏÀÒÎÏÐÎÒÅÊÒÎÐ ÏÐÈ ÖÓÊÐÎÂÎÌÓ Ä²À-ÁÅÒ² Äàíà ðîáîòà ì³ñòèòü îãëÿä äàíèõ ë³òåðàòóðè ùîäî ô³ç³î-ëîã³÷íî¿ ðîë³ ìåëàòîí³íó òà çíà÷åííÿ ìåëàòîí³íîâèõ ðåöåï-òîð³â ó ðåàë³çàö³¿ éîãî åôåêò³â. Ïîêàçàíî âïëèâ ìåëàòîí³íó íà ñèíòåç ³íñóë³íó, ïðîô³ëü ãëþêîçè òà éîãî çíà÷åííÿ â ïàòî-ãåíåç³ öóêðîâîãî ä³àáåòó. Òàêîae ðîçãëÿíóòî ìîaeëèâ³ ìåõàí³ç-ìè 䳿 ìåëàòîí³íó ÿê ôàðìàêîëîã³÷íîãî ïðåïàðàòó, à ñàìå, éîãî àíòèîêñèäàíòíèé åôåêò, âïëèâ íà ñèñòåìó îêñèäó àçîòó, âçàº-ìîä³þ ³ç ñïåöèô³÷íèìè ìåëàòîí³íîâèìè ðåöåïòîðàìè òà ³íø³. Âñ³ ö³ ìåõàí³çìè, éìîâ³ðíî, ëåaeàòü â îñíîâ³ éîãî ãåïàòîïðî-òåêòîðíîãî âïëèâó ïðè öóêðîâîìó ä³àáåò³.ÌÅËÀÒÎÍÈÍ ÊÀÊ ÃÅÏÀÒÎÏÐÎÒÅÊÒÎÐ ÏÐÈ ÑÀÕÀÐÍÎÌ ÄÈÀ-ÁÅÒÅ Ýòà ðàáîòà ñîäåðaeèò îáçîð äàííûõ ëèòåðàòóðû î ôèçèîëîãè÷åñêîé ðîëè ìåëàòîíèíà è çíà÷åíèå ìåëàòîíèíî-âûõ ðåöåïòîðîâ â ðåàëèçàöèè åãî ýôôåêòîâ. Ïîêàçàíî âëè-ÿíèå ìåëàòîíèíà íà ñèíòåç èíñóëèíà, ïðîôèëü ãëþêîçû è åãî çíà÷åíèå â ïàòîãåíåçå ñàõàðíîãî äèàáåòà. Òàêaeå ðàññìîòðå-íû âîçìîaeíûå ìåõàíèçìû äåéñòâèÿ ìåëàòîíèíà êàê ôàðìà-êîëîãè÷åñêîãî ïðåïàðàòà, à èìåííî, åãî àíòèîêñèäàíòíûé ýôôåêò, âëèÿíèå íà ñèñòåìó îêñèäà àçîòà, âçàèìîäåéñòâèå ñî ñïåöèôè÷åñêèìè ìåëàòîíèíîâûìè ðåöåïòîðàìè è äðó-ãèå. Âñå ýòè ìåõàíèçìû, âåðîÿòíî, ëåaeàò â îñíîâå åãî ãåïà-òîïðîòåêòîðíîãî äåéñòâèÿ ïðè ñàõàðíîì äèàáåòå.MELATONIN AS HEPATOPROTECTOR AT DIABETES This paper reviews scientific information about physiological role of melatonin and melatonin receptors value in implementing its effects. The effect of melatonin on the synthesis of insulin, glucose profile and its role in the pathogenesis of diabetes are also discussed. The predictable mechanisms of melatonins action of as a pharmacological drug, namely its antioxidant effects, effects on nitric oxide system, interaction with specific melatonin receptors, and others are shown. All these mechanisms are likely to underlie its hepatoprotective influence at diabetes.Êëþ÷îâ³ ñëîâà: ìåëàòîí³í, ìåëàòîí³íîâ³ ðåöåïòî-ðè, öóêðîâèé ä³àáåò, ïå÷³íêà.Êëþ÷åâûå ñëîâà: ìåëàòîíèí, ìåëàòîíèíîâûå ðå-öåïòîðû, ñàõàðíûé äèàáåò, ïå÷åíü.
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