Мелатонін Як Гепатопротектор При Цукровому Діабеті

Олещук, О. М.; Іванків, Я. І

doi:10.11603/2415-8798.2015.1.4569

Cited by 1 publication

(1 citation statement)

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“…Melatonin also inhibits the formation of peroxynitrite, a toxic oxidants, which formed with the participation of nitric oxide and superoxide anion in terms of pathology [33]. The effect of melatonin on lipid peroxidation, antioxidant enzymes and glutathione content at healthy rats was depicted in our previous work [34]. It was shown that the introduction of the agent promotes the inhibition of lipid peroxidation processes; enhance antioxidant protecting the body and link mitochondrial enzymes chain.…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective Effect of Melatonin in Toxic Liver Injury in Rats

et al. 2019

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Background and objectives: toxic liver injury results in nitrooxidative stress. Melatonin is a potent free radical scavenger, an inducible nitric oxide synthase (iNOS) inhibitor and an activator of antioxidant enzymes. The aim of this study was to investigate the hepatoprotective effect of exogenous melatonin on animals with acute toxic hepatitis. Material and methods: 36 healthy Sprague-Dawley male rats were split into three equal groups and given carbon tetrachloride (CCl4), 2 g/kg (CCl4 group) or the same dose of CCl4 and melatonin, 10 mg/kg (CCl4/melatonin group) or saline (control group). The effect of melatonin on prooxidant and antioxidant system indexes, NO and NOS levels in serum and liver, data of mitochondrial chain functions and cytolysis in liver were evaluated in all three groups. Results: melatonin significantly decreased activities of AST, ALT, ceruloplasmine and thiobarbituric acid reactive substance (TBARS) in serum. Catalase activity was lowered in serum but not in the liver. Hepatic TBARS, lipid hydroperoxides and glutathione concentrations were decreased, while superoxide dismutase, mitochondrial cytochrome oxidase and succinate dehydrogenase activities increased. Melatonin inhibited synthesis of stable NO metabolites in serum: NO2-by 37.9%; NO3-by 29.2%. There was no significant difference in content NO2-in the liver, but concentration of NO3-increased by 32.6%. Melatonin significantly reduced iNOS concentrations both in serum (59.7%) and liver (57.8%) but did not affect endothelial isoform enzyme activities neither in serum, nor in liver. The histopathological liver lesions observed in the CCl4/melatonin group were less severe than those seen in the CCl4 group. Conclusions: we demonstrated an ameliorating effect of melatonin on prooxidants and antioxidants, NO-NOS systems balance, mitochondrial function and histopathological lesions in the liver in rats with CCl4-induced hepatitis.

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Section: Discussionmentioning

confidence: 99%