Purpose: to evaluate the role of well-known factors on the formation of bone mineral density (BMD) and risk of fractures in primary osteoporosis in men. Patients and methods. The influence of well-known osteoporosis risk factors such as age, smoking, alcohol consumption, obesity, genetic disorders in genes encoding COL1A1, COL1A2 and VDR-receptor products, history of low-energy fractures in first-line relatives upon the BMD value and risk of fractures was evaluated in 231 patients with primary osteoporosis. All patients were divided into three age groups according to the following forms of osteoporosis: 17-20 years (n=26) - juvenile form, 21-50 (n=103) - idiopathic form, patients over 51 years (n=102). To assess the influence of study factors on the risk of fractures the patients were subdivided into 5 groups according to fracture localization. Results. The relationship between BMD deficit and mutations in homozygous form of gene rs2412298 (encodes collagen), and the tendency to a reliable increase of BMD deficit in L1 - L4 vertebrae under polymorphism in homozygous form of 1800012 gene was noted that might be evidence of their contribution to the development of primary osteoporosis in men. At the same time, smoking, alcohol consumption, age, mutations in homozygous form of gene rs2412298 and a history of low-energy fractures in first-line relatives increased the risk of low-energy fractures of the vertebral bodies and proximal femur.
Osteoporosis is a persistent social and medical issue taking into account moral and material losses related to bone fractures occurring against its background. The disease is more frequently examined in women than in men; still, according to EVOS (European Spinal Osteoporosis Study) 13.5 % men older than 50 and 26 % men older than 60 run high risks of fractures in case they have osteoporosis. Risk factors that cause both the disease itself and fractures as its complications have not been examined profoundly, even though men run 1.6 times higher risk of death after a fracture than women. There is an assumption that a reason for this higher mortality is lack of knowledge about risk factors that cause the disease and a fracture as one of its complications. Growing morbidity with osteoporosis among men indicates it is necessary to perform activities aimed at persuading them to pursue healthy lifestyle. Given that, it seems important to assess impacts exerted by smoking and alcohol abuse on risks of fractures among patients with primary osteoporosis bearing in mind prevention of the disease and fractures as its complications. We examined a relation between smoking and alcohol abuse and risks of fractures as osteoporosis markers in 231 patients suffering from primary osteoporosis. We revealed that fractures were authentically more frequent among smoking patients, 90.5 % against 68.1 % (р˂0.001). It was primarily true for fractures of the proximal section in the thigh bone and fractures of vertebral bodies: 20.2 % against 8.8 % and 44.1 % against 27.3 % accordingly. Alcohol abuse also resulted in authentically higher risks of fractures, 89.8 % against 66.2 % accordingly (р˂0.001). Authentic discrepancies were detected only for fractures of vertebral bodies, 43.9 % against 23.6 % accordingly among those who didn't abuse alcohol (р˂0.001). Therefore, we have evidence that there is an authentic relation between smoking and alcohol abuse and risks of fractures of the proximal section in the thigh bone and vertebral bodies. Inclusion of our research results into educational programs may lead to a reduction in frequency of fractures that have the gravest outcomes for health and cause the highest economic losses.
Hypophosphatasia is a rare inborn error of metabolism caused by mutations in the gene encoding tissue-nonspecific isoenzyme of alkaline phosphatase. Inexpressive clinical picture of the disease in adults is often difficult to diagnose. We present two clinical observations: in one case, the patient was treated for a long time with alfacalcidol and calcium supplementation due to misdiagnosis of systemic osteoporosis with pathologic fractures of the vertebras, although at the presentation the patient had a typical for hypophosphatasia decrease of alkaline phosphatase. In another case, a patient with diagnosis of aseptic necrosis of the femoral head had a sharp decrease in alkaline phosphatase levels at presurgical evaluation. In both cases, the diagnosis was confirmed by genetic testing. For patients with aseptic necrosis the confirmation of the diagnosis of hypophosphatasia determines the need for treatment with asfotase alfa in the postoperative period to preserve the stability of the endoprosthesis.
A literature review is devoted to acute and chronic pain mechanisms in vertebral fractures complicating osteoporosis. The data of pharmacological and non-pharmacological methods of pain relief for vertebral bodies fractures, which precede the pathogenetic therapy of osteoporosis or could be combined with it.
Purpose:to evaluate the role of well-known factors on the formation of bone mineral density (BMD) and risk of fractures in primary osteoporosis in men.Patients and methods.The influence of well-known osteoporosis risk factors such as age, smoking, alcohol consumption, obesity, genetic disorders in genes encoding COL1A1, COL1A2 and VDR-receptor products, history of low-energy fractures in first-line relatives upon the BMD value and risk of fractures was evaluated in 231 patients with primary osteoporosis. All patients were divided into three age groups according to the following forms of osteoporosis: 17-20 years (n=26) – juvenile form, 21-50 (n=103) – idiopathic form, patients over 51 years (n=102). To assess the influence of study factors on the risk of fractures the patients were subdivided into 5 groups according to fracture localization.Results.The relationship between BMD deficit and mutations in homozygous form of gene rs2412298 (encodes collagen), and the tendency to a reliable increase of BMD deficit in L1 – L4 vertebrae under polymorphism in homozygous form of 1800012 gene was noted that might be evidence of their contribution to the development of primary osteoporosis in men. At the same time, smoking, alcohol consumption, age, mutations in homozygous form of gene rs2412298 and a history of low-energy fractures in first-line relatives increased the risk of low-energy fractures of the vertebral bodies and proximal femur.
The article presents the results of 5-year treatment with a combination of alfacalcidol and calcium carbonate in 47 men with primary forms of systemic osteoporosis. The obtained results show the effectiveness of this treatment in patients with low and normal turnover forms of osteoporosis. Significant increase of BMD at L1-L4 was observed after the first year of treatment, at the Neck region - after 3-rd year of treatment. Comparison of the magnitude of the annual increase of BMD has shown that the effectiveness of the treatment increases with its duration. The possibility of hypercalcemia was excluded by monitoring of calcium levels in blood and urine at intervals of 3-6 months throughout the treatment period.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.