The derivatives of fatty acids are considered as promising bases for the development of medicinal and cosmetic agents. In this regard, it is necessary to study their potential toxicity, including chronic. In repeated toxicity experiments on mice of C57BL6 line, the administration of N-palmitoyl-5-aminolevulinic acid (within liposomes) for 62 days was less toxic than N-palmitoylglycine injected in the same regimen, which resulted in lower mortality of animals. The toxic effects of high doses, both PalGly and Pal-5-ALA, are characterized by a gender dependence: males were more sensitive to PalGly, whereas females - to Pal-5-Ala. Chronic administration of liposomes of phosphatidylcholine (without N-acylamino acids) caused the death of several mice, suggesting that the toxic effects of PalGly and Pal-5-ALA in liposomal form are at least partly due to the influence of the liposomes themselves.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.