IntroductionNormally, thyroid hormones are important regulators of metabolic processes in mammals [1,2]. With the ability to regulate transcription of specific proteins, iodothyronine ensure the maintenance of optimal level of metabolic processes [3,4]. Furthermore, the results of modern studies show direct evidence of the importance of the role of thyroid hormones in the processes of adaptation to the adverse geophysical factors [5]. In the literature discussed ways of involving iodothyronine formation in response to changes in the parameters of homeostasis [4,6,7].However, the flow of thyroid diseases are accompanied by violations of water-salt metabolism, pathophysiological mechanisms which require further study [8,9,10]. Published research results underscore the relevance of the analysis renotrop effects of thyroid hormones, as well as provide direct evidence for regular changes of homeostatic kidney function in hyperthyroidism [8,9,11]. Some review publications suggests that the symptoms characteristic of thyreopathology, including renal, can be eliminated by successful correction of the thyroid status of the organism [9,11,12]. Thus, the findings presented in the cited sources suggest that pathological changes in the synthesis and secretion of thyroid hormones due to hypo-or hyperfunction of the secretory epithelium of the thyroid gland, the main cause that determines the dynamics of changes of the kidneys and the intensity of the renal manifestations symptoms, accompanying thyreopathology. Therefore, efficient treatment of the underlying disease creates a favorable background correction dysfunction of internal organs, including kidneys. Meanwhile, in the literature, there are some reports that the restructuring of the kidney is registered within the first few hours after a single dose of an animal of exogenous thyroxine [13], with chronic experimental hyperthyroidism can cause irreversible structural changes of renal parenchyma, not only resolves the correction of thyroid status [11,14]. AbstractIntroduction: Normally, thyroid hormones are important regulators of metabolic processes in mammals.
THE AIM: to study of the dynamics of structural changes in renal parenchyma of rats exposed to long-term combined effects of thyroxine and propylthiouracilum (PTU). MATHERIAL AND METHODS – studies were performed on mongrel white male rats weighing 250-300g. Hyperthyroidism was caused by daily intragastric administration of thyroxine (T4) in amount of 50g per 100g of body weight over 30 days. On the first day of the experiment animals were divided into 2 groups. Animals of the first group (n = 25) received only T4. The rats of the second group (n = 25) were administrated propylthiouracilum and T4 daily. PTU was administered intragastric in amount of 1 mg per 100g of body weight. Kidney tissue samples were collected on the 10th, 20th and 30th days of the experiment. In addition, there were collected kidney tissue samples of the animals treated with only T4 after 20 days after cessation of hormone. Obtained tissue samples were fixed and treated by the usual method, followed by filling in paraffin. Sections were stained with hematoxylin and eosin. RESULTS – it was established that course of experimental hyperthyroidism leads to significant structural abnormalities of the renal parenchyma. Leading features of kidneys pathology at a hyperthyroidism are rough structural damages of the nephron tubular epithelium. CONCLUSIONS – combined administration in rats of thyroxin and propylthiouracilum has weakly expressed beneficial effect by limiting the development of structural damages to the renal parenchyma and clot formation.
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