Experimental Investigation of Acute and Delayed Renal Effect of Exogenous Thyroxine

Abstract

IntroductionNormally, thyroid hormones are important regulators of metabolic processes in mammals [1,2]. With the ability to regulate transcription of specific proteins, iodothyronine ensure the maintenance of optimal level of metabolic processes [3,4]. Furthermore, the results of modern studies show direct evidence of the importance of the role of thyroid hormones in the processes of adaptation to the adverse geophysical factors [5]. In the literature discussed ways of involving iodothyronine formation in response to changes in the parameters of homeostasis [4,6,7].However, the flow of thyroid diseases are accompanied by violations of water-salt metabolism, pathophysiological mechanisms which require further study [8,9,10]. Published research results underscore the relevance of the analysis renotrop effects of thyroid hormones, as well as provide direct evidence for regular changes of homeostatic kidney function in hyperthyroidism [8,9,11]. Some review publications suggests that the symptoms characteristic of thyreopathology, including renal, can be eliminated by successful correction of the thyroid status of the organism [9,11,12]. Thus, the findings presented in the cited sources suggest that pathological changes in the synthesis and secretion of thyroid hormones due to hypo-or hyperfunction of the secretory epithelium of the thyroid gland, the main cause that determines the dynamics of changes of the kidneys and the intensity of the renal manifestations symptoms, accompanying thyreopathology. Therefore, efficient treatment of the underlying disease creates a favorable background correction dysfunction of internal organs, including kidneys. Meanwhile, in the literature, there are some reports that the restructuring of the kidney is registered within the first few hours after a single dose of an animal of exogenous thyroxine [13], with chronic experimental hyperthyroidism can cause irreversible structural changes of renal parenchyma, not only resolves the correction of thyroid status [11,14]. AbstractIntroduction: Normally, thyroid hormones are important regulators of metabolic processes in mammals.

Influence of Combined Injection of Thyroxin and Propylthiouracilum on Sctructural Indicators of Renal Parenchyma

“…Большинство исследователей придерживаются мнения о том, что по мере нормализации тиреоидного статуса организма происходит восстановление функции почек. Однако ранее проведенные исследования показывают, что, во-первых, изменения почечного транспорта натрия, индуцированные гипертиреозом, сохраняются достаточно продолжительное время после нормализации тиреоидного статуса организма [8]. Во-вторых, было установлено, что продолжительное введение крысам тироксина приводит к грубым структурным повреждениям сосудистоклубочкового и канальцевого отделов нефрона, соответствующих представлению о хронической болезни почек (ХБП) [9].…”