The human body, like any other, is an intermediate component of the nitrogen cycle in nature. Consuming nitrogen from the external environment in the form of various compounds, the body processes it into ammonia - one of the final products of exchange of nitrogen-containing substances [1], which is removed from the body in the form of urea. The most active ammonia producers are organs with high exchange of amino acids and biogenic amines - nerve tissue, liver, intestine, and muscles. In a state of nitrogen equilibrium, the adult body consumes and releases about 15 g of nitrogen per day, temporary or permanent disruption of nitrogen balance results in a great number of physiological conditions and diseases, and the need to stabilize it is well known. However, despite a huge number of studies on the role of nitrogen metabolism and its compounds in the clinic, to date we have not been able to find any conciliation document in the world literature on the classification of ammonia-ammonium levels in human blood and approaches to the correction of hyperammonemia, which was the basis for the emergence of this consensus.
The therapeutic and preventive measures for patients with COPD and MS should involve educational programs and physical trainings, which are developed, by taking into account of a comorbidity in order to optimize therapeutic and preventive measures and to improve quality of life in this category of patients.
The purpose of this study was to assess the characteristics of the clinical course of asthma in patients with metabolic syndrome (MetS) and to analyze the influence of the MetS components on the course of asthma, control of asthma symptoms, and the the quality of life (QL) of patients with asthma.
Materials and Methods:We examined 95 asthma patients aged from 18 to 60 years. The patients were divided into 2 groups. Group 1 included 35 patients without MetS (24/68.6% women and 11/31.4% men; mean age, 49.81±0.77 years), and Group 2 included 60 patients with MetS (45/75.0% women and 15/25.0% men; mean age, 49.82±0.77 years). The asthma diagnosis was based on the integral assessment of symptoms, medical history, health status, and spirometry values according to the Global Strategy for Asthma Management and Prevention (2017). MetS was diagnosed according to the IDF consensus criteria (2006).Results: The MetS components, such as central obesity, high blood pressure, dyslipidemia, carbohydrate metabolism disorder, cause a more serious and unfavorable course of asthma, with frequent exacerbations, calls to emergency service and hospital admissions, severe asthma symptoms, uncontrolled asthma symptoms, low spirometry results, and low level of QL in the physical and psychological domains.
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