Impact of Metabolic Syndrome Components on Asthma Control and Life Quality of Patients

Budnevsky, A. V.; Tribuntceva, Ludmila; Кожевникова, С. А.; Ovsyannikov, Evgeniy

doi:10.21103/article8(1)_oa4

Cited by 3 publications

(2 citation statements)

References 3 publications

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“…The comorbid course of these pathologies aggravates the prognosis of patients. [2,3] In order to improve the efficiency of CHF and COPD management, various methods of influencing the pathogenesis of these diseases are used [4,5]. Moderate physical activity is recommended as a non-drug therapy for both pathologies [6,7].…”

Section: Introductionmentioning

confidence: 99%

Physical Rehabilitation in Patients with Chronic Heart Failure and Chronic Obstructive Pulmonary Disease

Tokmachev¹,

Budnevsky²,

Kravchenko³

et al. 2022

PJMHS

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Despite all the efforts of medical services, the socio-economic damage caused by chronic heart failure (CHF) is increasing. Approximately 10-40% of patients with CHF also suffer from chronic obstructive pulmonary disease (COPD). The comorbid course of these pathologies aggravates the prognosis of patients. Moderate physical activity is recommended as a non-drug therapy for both pathologies. The aim of the study: was to evaluate the effectiveness of physical rehabilitation in patients with chronic heart failure and chronic obstructive pulmonary disease by determining the levels of NT-proBNP, high-sensitivity C-reactive protein, IL-1β, IL-6, TNF-α. Methods: The study included 240 patients with CHF. After the initial examination, the patients were divided into groups depending on the presence or absence of COPD and the value of LVEF. Subsequently, each group was divided into a subgroup that took part in physical rehabilitation in addition to standard medical therapy and another one consist of patients that received only standard therapy. A year later, the levels of NT-proBNP, high-sensitivity C-reactive protein, IL-1β, IL-6 and TNF-α were re-determined. Results and Conclusion: CHFpEF patients have higher levels of hs-CRP and pro-inflammatory cytokines compared to patients with CHFrEF. The combination of COPD and CHF enhances systemic inflammation and myocardial remodeling processes, determined by the level of NT-proBNP in comparison with the isolated course of CHF. Physical rehabilitation in patients with a comorbid course of COPD and CHF is accompanied by a significant decrease in the levels of pro-inflammatory cytokines, hs-CRP and NT-proBNP. Keywords: chronic heart failure, chronic obstructive pulmonary disease, physical rehabilitation

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Section: Introductionmentioning

confidence: 99%

Physical Rehabilitation in Patients with Chronic Heart Failure and Chronic Obstructive Pulmonary Disease

Tokmachev¹,

Budnevsky²,

Kravchenko³

et al. 2022

PJMHS

View full text Add to dashboard Cite

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“…It is the heterogeneity of the disease that dictates the need for the most individualized treatment. (1,2) The heterogeneity of both clinical manifestations of asthma and response to therapy is considered nowadays. (3,4) We distinguish many asthma phenotypes, and even subphenotypes, based on those factors.…”

Section: Introductionmentioning

confidence: 99%

Clinical Phenotype “Obesity-Asthma” as One of the Main Problems of Personalized Pulmonology

Tribuntceva¹,

Shkatova²,

Авдеев³

et al. 2019

IJBM

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Background: Asthma is a heterogeneous disease comprising different phenotypes. One of the most common asthma phenotypes is the obesity-asthma phenotype, since obesity affects over a third of the world's population today. It is important to continue investigating possible underlying mechanisms of the interaction between asthma and obesity. The purpose of this study was to evaluate levels of leptin, adiponectin, neuropeptide Y (NPY), total oxidative damage (TOD), and total antioxidant status (TAS) in patients with asthma and different body weight (BW), and to analyze their association with spirometry parameters. Materials and Methods: The study included 27 men and 86 women diagnosed with moderate asthma (mean age of 57.81±13.05 years). During the study, all asthma patients were divided into 3 groups. Group 1 included 37 patients with normal BW, Group 2 included 38 overweight patients, and Group 3 included 38 patients with obesity. We analyzed complaints, anamnesis data, objective status data, and laboratory (blood levels of NPY, adiponectin, leptin, total antioxidant status, and total oxidative damage) and instrumental data (spirometry). Two questionnaires were used: Asthma Quality of Life Questionnaire (AQLQ) and Asthma Control Test (АСТ). Results: The leptin level was significantly higher in Group 3 compared to Groups 1 and 2 (P=0.000). The NPY level was significantly lower in Group 1 compared to Groups 2 and 3 (P=0.000). The TAS value was significantly higher in Group 1 compared to Groups 2 and 3 (P=0.000) and the TOD value in Group 1 was significantly lower than in Group 3 (P=0.038).The leptin level positively correlated with BMI and waist circumference, and had an inverse correlation with FEV 1 and vital capacity (VC). The adiponectin level had a positive correlation with the Tiffno index, FEF 50 , and peak expiratory flow (PEF). The NPY level had an inverse correlation with VC, FEV 1 , FEF 25 , FVC, Tiffno index, FEF 50 , and PEF. Conclusion: The severity of the clinical course of moderate asthma in obese patients is associated with different factors, including oxidative stress and levels of leptin, adiponectin and NPY.

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Female-biased association of NOS2-c.1823C>T (rs2297518) with co-susceptibility to metabolic syndrome and asthma

Aftabi

Gilani

Ansarin

et al. 2023

Can. J. Physiol. Pharmacol.

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The nitric oxide (NO) pathway contributes to the pathogeneses of metabolic syndrome (MetS) and asthma. NOS2 encodes inducible-NO synthase, which is an important enzyme of the pathway and its variations could affect the risk of asthma and MetS and thereby co-susceptibility to them. This study aimed to estimate the association of NOS2-c.1823C>T with risk of asthma, MetS, and asthma with MetS condition (ASMetS), and with asthma stages: intermittent, mild, moderate, and severe asthma. The study included asthmatics (n=555), MetS (n=334), and ASMetS cases (n=232) and 351 controls, which were genotyped by the PCR-RFLP method. The T allele was significantly associated with an increased risk of asthma and MetS in the sample population and females. CT genotype and CT+TT model were significantly associated with increased risk of ASMetS in females. A significant association between CT genotype and increased risk of ASMetS in the sample population and females was found in ASMetS vs. MetS. T allele significantly affects the risk of severe asthma in the sample population and females. The rs2297518 SNP of NOS2 contributes to the risk of MetS, asthma, and co-susceptibility to them, and this contribution may be stronger in females compared to males.

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Impact of Metabolic Syndrome Components on Asthma Control and Life Quality of Patients

Cited by 3 publications

References 3 publications

Physical Rehabilitation in Patients with Chronic Heart Failure and Chronic Obstructive Pulmonary Disease

Physical Rehabilitation in Patients with Chronic Heart Failure and Chronic Obstructive Pulmonary Disease

Clinical Phenotype “Obesity-Asthma” as One of the Main Problems of Personalized Pulmonology

Female-biased association of NOS2-c.1823C>T (rs2297518) with co-susceptibility to metabolic syndrome and asthma

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