The purpose of this work is the study of microcirculation state at different local effects of reactive oxygen species on animal tissues. The experiment was performed on 60 healthy white Wistar rats. Control group (without any manipulations) included 20 Wistar rats. Also 4 main groups were formed (10 rats in each). Rats of the first group (n=10) were intracutaneously injected with 1 ml of oxygen (in the back), a local darsonvalization during 4 min. was carried out in animals of the second group (n=10). In third group (n=10) the injection of 1 ml of oxygen-ozone mixture was made, in the fourth group (n=10) - darsonvalization during 4 min. after a preliminary introduction of oxygen (1 ml). Microcirculation parameters were tested by laser Doppler flowmetry with LAKK-02 device. It was defined, that local effects of reactive oxygen species include microcirculation changes, depending from specialties of exposed factor.
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