Some features of organism response on local administration of reactive oxygen

Перетягин,; Peretyagin, P. V.; Kovaleva,; Kovaleva, Lida K.; Peretyagin, S. P.; Мартусевич,; Мартусевич, А. К.; Лучникова,; Luchnikova, E.

doi:10.12737/16775

Cited by 3 publications

(1 citation statement)

References 5 publications

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“…Если выдвинутая гипотеза верна и направление ответа на действие низкоинтенсивного ЭМИ оптического диапазона будет зависеть от фонового уровня оксидативных процессов, то искусственное изменение окислительной напряженности в живой системе может модулировать ее отклик на воздействие. В качества системного модулятора уровня окислительных процессов в организме при опухолевом росте наиболее оптимально использовать озон [13][14][15][16][17][18], а для усиления генерации активных форм кислорода непосредственно в ткани неоплазии -искусственные фотосенсибилизаторы [19].…”

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Features of Photobiomodulation During Oncogenesis Depending on the Intensity of Oxidative Processes in the Organism of Rats

Pozdnyakova,

Zhukova

2024

Russian Journal of Biological Physics and Chemisrty

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In work tested the hypothesis that the antitumor efficacy of photobiomodulation (PBM) depends on the intensity of oxidative modification of macromolecules. The level of oxidative processes in the body was judged by the content of ROS-induced products of lipid, protein, and DNA modification, as well as the activity of the antioxidant enzymes superoxide dismutase (SOD) and catalase in biological tissues and fluids. It is proposed to use the behavioral activity of animals in the "open field" test as a non-invasive indicator for predicting the biological effects of photobiomodulation, indirectly reflecting the degree of oxidative stress in the body. It was shown that the level of behavioral activity correlates with SOD activity in the liver (ρ=0.8, p < 0.03, Spearman's test). Among laboratory rats, animals with passive, moderately active and highly active types of behavior can be distinguished. Each type is characterized by different severity of oxidative processes, growth dynamics of model solid tumors, and response to PBM in the violet-blue and red regions of the spectrum. Intraperitoneal exposure to ozonized saline with an ozone concentration of 0.16 μg/kg modulates the antitumor effect of PBM. It is concluded that the effectiveness of PMB during oncogenesis depends on the intensity of oxidative processes in the body and is interrelated with the behavioral characteristics of rats.

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Features of Photobiomodulation During Oncogenesis Depending on the Intensity of Oxidative Processes in the Organism of Rats

Pozdnyakova,

Zhukova

2024

Russian Journal of Biological Physics and Chemisrty

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Examination of the Microvasculature During Wound Process of the Oral Mucosa when Using Dual-Wavelength Photodynamic Therapy: a Pre-Clinical Experimental Randomized Study

Durnovo,

Tarakanova,

Shakhova

et al. 2023

Kuban. nauсh. med. vestnik

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Background. Healing of open wounds in the oral cavity is often accompanied by infection and constant traumatization, which lead to impaired blood supply to the tissues, lack of trophic support and low oxygen supply to increasing proliferative processes. Recently, photodynamic therapy has taken its place among the methods for stimulating regeneration of oral mucosal tissues. The authors consider it essential to study the influence of photodynamic treatment on the functional state of the microvasculature in the wound tissues, which determines the transcapillary exchange and the tissue respiration, providing the tissue regeneration.Objective. To study the photodynamic effect of sequential dual-wavelength radiation on the microvasculature in the wound tissues of the oral mucosa in vivo.Methods. The study was carried out on 36 female outbred Wistar rats, weighing 200–250 g. The animals were divided into two groups: control group (n = 18) and experimental group (n = 18). Wound surfaces healed by secondary intention were modeled on the cheek mucosa of the animals. Dual-wavelength photodynamic therapy was performed in the 1st postoperative day in experimental group. The microcirculatory function was assessed by Doppler flowmetry before, and on days 3, 7 and 14 after wounding. The results were processed using IBM SPSS Statistics 26.0.0.1 (IBM Inc., USA).Results. It has been established that dual-wavelength photodynamic therapy has a positive effect on the restoration of the microvasculature of the wound tissues. This therapy facilitated bypassing for microcirculatory flow on the 3rd day of the study, and increased the perfusion of tissues on the 7th. The experimental group did not have congestive-ischaemic phenomena in the wound region; the microcirculatory flow was augmented through the microcirculation regulation by the 14th day.Conclusion. Following the obtained results the use of dual-wavelength photodynamic therapy can be considered as a promising method for restoration of the microvasculature of tissues in the oral mucosal trauma.

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About the possibility of using physiotherapy in the practice of a surgeon. Literature review

et al. 2021

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Physiotherapy is a field of medicine based on the study and application of natural and artificially created natural factors on the human body. Physical factors can have both local and systemic effects on the patient’s body. In the postoperative period, physiotherapy helps to solve the most important problems, such as accelerating the processes of tissue regeneration and reducing the risk of infection in the area of surgery. Physical factors, activating fibroblasts, accelerate the synthesis of collagen fibers and increase the regenerative capacity of damaged tissues. In addition, due to bacteriostatic and bactericidal action, microorganisms are destroyed and the risk of postoperative infectious complications is reduced. Understanding the key features of all stages of the wound process allows you to rationally affect the wound. The use of an integrated approach based on drug therapy and the use of physiotherapy procedures significantly increases the effectiveness of treatment and helps the patient to return to their usual level of life as soon as possible. This article is a review of the literature on the most commonly used methods of physiotherapy in the postoperative period. Based on the analysis of publications, the article presents the features and principle of operation of such techniques as electrophoresis, phonophoresis, magnetotherapy, ozone therapy, electrical stimulation, cryotherapy, shock wave therapy, galvanization, darsonvalization, as well as therapy based on the effects of ultraviolet radiation, laser, ultrasound, microcurrents. Examples of physiotherapeutic procedures that should be used at various stages of the wound process, depending on the impact, are given. It is the use of various methods of influence in combination with each other that helps to achieve the maximum effect of treatment in the postoperative period.

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Some features of organism response on local administration of reactive oxygen

Cited by 3 publications

References 5 publications

Features of Photobiomodulation During Oncogenesis Depending on the Intensity of Oxidative Processes in the Organism of Rats

Features of Photobiomodulation During Oncogenesis Depending on the Intensity of Oxidative Processes in the Organism of Rats

Examination of the Microvasculature During Wound Process of the Oral Mucosa when Using Dual-Wavelength Photodynamic Therapy: a Pre-Clinical Experimental Randomized Study

About the possibility of using physiotherapy in the practice of a surgeon. Literature review

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