One of the risk factors that plays an important role in the pathogenesis but is insufficiently studied in the development and progression of hypertension (AH) is the presence of connective tissue dysplasia (СTD). CTD are genetically determined conditions characterized by defects in fibrous structures and the main substance of connective tissue (CT), which lead to disruption of the formation of organs and systems, have a progressive course and determine the features of the associated pathology.The objective: study of the frequency and severity of mitral valve prolapse in patients with hypertension.Materials and methods. We examined 153 patients with primary hypertension I–II stage 1 – 3 degrees (90 men and 63 women) aged 22 to 45 years.Results. Mitral valve prolapse (MVP) was detected in 32 % of patients with hypertension (grade 1 MVP – in 21 % of patients and grade 2 – in 11 %, respectively. The frequency of MVP in stage I hypertension was established than in stage II. MVP with mitral regurgitation of 1–2 degrees was higher in hypertension of stage II in comparison with AH of stage I. MVP of 1 degree was most often associated with increased variability of systolic blood pressure (SBP), and MVP of 2 degree – with increased SBP load and type of daily profile «non-dipper» BP was characterized by a higher incidence of left ventricular hypertrophy (LVH) and supraventricular arrhythmias than in patients without MVP, with an increase in the concentration of free oxyproline in the blood in patients with grade 1 hypertension and total oxyproline – in patients with hypertension with MVP 2 degree.Conclusions. It was found that 32 % of patients with hypertension of young and middle age have MVP 1–2 degrees. An increase in the frequency of MVP in general (1 and 2 degrees) in patients with stage I hypertension, compared with patients with stage II hypertension, as well as the frequency of stage 1 MVP in patients with stage I hypertension compared with patients with stage II hypertension. At the same time, the frequency of MVP 2 degree and MVP with MR 1–2 degree was higher in patients with stage II hypertension compared with stage I hypertension. Patients with hypertension with MVP were characterized by a higher frequency of LVH and the occurrence of supraventricular arrhythmias than for patients without MVP. There was a significant increase in blood levels of free oxyproline in the group of patients with hypertension with MVP 1 degree compared with patients with MVP 2 degree and a significant increase in blood levels of total oxyproline in patients with MVP 2 degree compared with patients with MVP 1 degree.
The global process of transition to the information society, as well as the economic, political and social changes that accompany it, are accelerating the reform of the education system. Distance learning is a humanistic personality-oriented form of learning, the basis of which is purposeful, motivated learning and communication between the teacher and students by using of modern information technology. The distance learning system opens wide access to various educational services to a large number of people who, due to objective or subjective reasons, cannot receive education in the traditional way. In addition, the advantage of this form of education is the lack of «age requirements», which is sometimes an objective obstacle to retraining or additional education for those categories of people with professional experience. The purpose of the study was to analyze the features of teaching a distance course in the discipline «Laboratory Diagnostics», developed at the Department of Clinical Laboratory Diagnostics National university of pharmacy. Material and methods. The methodological basis of the study included the following components: system approach; the concept of personality-oriented learning; principles of distance learning; theory of information systems. The article considers the peculiarities of the organization of distance learning in National university of pharmacy, the main methodological regulations on which the introduction of distance learning courses is based. The distance courses of the discipline «Laboratory Diagnostics» for students of specialty 226 «Pharmacy, Industrial Pharmacy» in the information environment Moodle was analyzed and generalized and the basic elements of educational information placement were directly described. The authors determined the place of distance courses in the process of independent training of educational process; the special role of the teacher (tutor) in the organization of independent training of the students according to the offered methodical recommendations and distance courses was shown. Conclusion. Distance learning in a virtual educational environment provides a variety of modern e-learning tools that can be used not only in full-scale distance learning, but also in traditional forms. National university of pharmacy is actively implementing measures to comply with the requirements of current regulations of the Ministry of Education and Science of Ukraine on the implementation of distance learning. The experience of teaching the discipline «Laboratory Diagnostics» using distance learning technology allows future professionals in the field of knowledge «Health» to acquire skills and abilities
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