The purpose of the study was to examine the levels of transforming growth factor-β1 in the serum of patients with coronary heart disease in combination with type 2 diabetes and without it. Material and methods. We conducted a survey of 65 patients (25 men, 40 women) aged from 36 to 69 years (mean age was (59±3.5) years). All patients were diagnosed with coronary heart disease in the form of stable angina pectoris I-II functional classes. The group of examined patients included 33 patients with concomitant type 2 diabetes mellitus (mild form was in 15 people; moderate was in 18 people) and 32 patients without diabetes mellitus. The scope of the survey covered the generally accepted methods of clinical, laboratory and instrumental examination. The group of patients with coronary heart disease with type 2 diabetes had 14 (43%) men and 19 (57%) women (mean age was (62±2.6) years. Heart failure of stage I-II A (I-II functional classes) was diagnosed in 22 (68%) patients. The duration of coronary heart disease was from 3 to 15 years, the duration of type 2 diabetes lasted from 3 to 14. We detected hypertension in 19 (57%) patients, it was within 1-2 degrees (according to the criteria of the Ukrainian Association of Cardiologists, 2008). In the group of patients with coronary heart disease without diabetes there were 11 men (34%), 21 women (66%) (mean age was (57.0±2.4) years). Hypertension within 1-2 degrees was detected in 15 (46%) patients. Heart failure of I-II A stages (I-II functional classes) was diagnosed in 15 (46%) patients. The control group consisted of 15 practically healthy individuals who were representative by sex and age of patients from the study group and who did not have diseases of the cardiovascular system and endocrinopathies. The level of transforming growth factor-β1 in the blood serum was determined using sets of standard test systems "TGF-β1 ELISA" produced by company "DRG Instruments" (Germany). The level of native transforming growth factor-β1 in the serum was determined by solid-phase enzyme-linked immunosorbent assay. Results and discussion. Groups of patients with coronary heart disease with type 2 diabetes and without it could be compared by age, sex, duration and severity of coronary heart disease, the frequency of concomitant hypertension. At the same time, among patients with coronary heart disease with type 2 diabetes there was a higher frequency of heart failure. The results showed that probable increase in serum transforming growth factor-β1 levels in patients with coronary heart disease was more pronounced when combining coronary heart disease with type 2 diabetes. There was a significant increase in serum of transforming growth factor -β1 levels in patients with coronary heart disease both with type 2 diabetes and without it with a longer course of coronary heart disease and were severer, in patients with coronary heart disease with type 2 diabetes was with a longer course of diabetes. Analysis of the nature of changes in the levels of transforming growth factor-β1 in the serum of the examined patients with coronary heart disease with type 2 diabetes and without it, depending on gender, did not reveal any significant differences. The results of the study also indicated that in patients with coronary heart disease with type 2 diabetes and without it for all duration of coronary heart disease, the levels of this indicator in the serum were probably (p <0.05) higher than those in the control group. However, in patients with a significant duration of coronary heart disease (5-10 years and over 10 years) serum levels of transforming growth factor-β1 were probably (p <0.05) higher than in patients with a duration of coronary heart disease less than 5 years, and in the presence of and in the absence of type 2 diabetes. At the same time, for all periods of coronary heart disease, the levels of transforming growth factor-β1 in patients with type 2 diabetes were probably higher than in patients without diabetes. Conclusion. A probable increase in the levels of transforming growth factor -β1 in the serum of patients with coronary heart disease, which was more pronounced when combining coronary heart disease with type 2 diabetes. There was a significant increase in the levels of transforming growth factor-β1 in the serum of patients with coronary heart disease both with type 2 diabetes and without it with a longer course of coronary heart disease and its severe degree, in patients with coronary heart disease with type 2 diabetes especially with a longer course of diabetes. In order to increase the informativeness of assessing the risk of cardiovascular complications and the nature of coronary heart disease in patients with type 2 diabetes, the survey should include determination of serum levels of potent profibrogenic factor like transforming growth factor-β1
Цель. Изучение влияния ранней реваскуляризации миокарда на течение острого коронарного синдрома (ОКС) без подъема сегмента ST, осложненного желудочковой экстрасистолией (ЖЭ) с высоким риском развития жизнеугро-жающих желудочковых аритмий (ЖЖА). Материал и методы. Наблюдалось 124 больных ОКС без подъема сегмента ST, осложненным ЖЭ II-V класса по Лауну, с высоким риском развития ЖЖА, который расценивался при наличии патологических значений линейного отклонения предэктопического интервала ЖЭ и индекса риска развития ЖЖА, составившие ≤10 мс и ≤0,5, соответственно. Всем больным, при наличии информированного согласия, в первые 24 ч с момента поступления в стацио-нар проводилась оценка проходимости венечных артерий и при выявлении показаний -реваскуляризация миокарда, а при отказе от инвазивного вме-шательства -дополнительно к проводимой терапии использовались препа-раты III класса, представленные преимущественно амиодароном. Результаты. Наилучший положительный эффект реваскуляризации у больных ОКС без подъема сегмента ST, осложненным ЖЭ с высоким риском развития ЖЖА, наблюдался при ее проведении в течение 2 ч с момента поступления в стационар: фатальные желудочковые аритмии как на госпитальном этапе, так и после выписки из стационара, не регистрировались. Эффективность предупреждения фатальных желудочковых аритмий у больных ОКС без подъема сегмента ST, осложненным ЖЭ с высоким риском развития ЖЖА, при использовании реваскуляризации миокарда, при наличии показа-ний, в течение от 2 ч до 24 ч после поступления в стационар на госпитальном этапе была сопоставима с применением дополнительно к проводимой тера-пии препаратов III класса -в частности, амиодарона, и составила в среднем 76,19% и 79,41%, соответственно. Заключение. Всем больным ОКС без подъема сегмента ST, осложненным ЖЭ с высоким риском развития ЖЖА, показано проведение реваскуляризации миокарда при наличии показаний в первые 2 ч после поступления в стационар. Aim. To study the role of early myocardial revascularization in the clinical course of the acute coronary syndrome (NSTEACS) without ST elevation, complicated with ventricular extrasystoly (VE) and high risk of life-threatening ventricular arrhythmias (LVA) development. Material and methods. Totally 124 patients with NSTEACS with VE II-V Lown and high risk of LVA that was assessed if there are pathologic values of linear shift of preectopic VE interval and LVA index, ≤10 ms and ≤0,5, respectively. To all patients having informed consent during the first 24 h since admittance the evaluation of coronary arteries flow grade was performed and for those having indicationsrevascularization preformed. In refusion of invasive treatment -in addition to conservative therapy the drugs of III class were used (mostly amiodarone). Results. The best positive effect of revascularization in NSTEACS with VE and LVA risk was if it had been performed during the first 2 h since hospitalization: fatal ventricular arrhythmias during hospitalization and before were not registered.Efficacy of fatal arrhythmias prevention in NSTEACS...
The global process of transition to the information society, as well as the economic, political and social changes that accompany it, are accelerating the reform of the education system. Distance learning is a humanistic personality-oriented form of learning, the basis of which is purposeful, motivated learning and communication between the teacher and students by using of modern information technology. The distance learning system opens wide access to various educational services to a large number of people who, due to objective or subjective reasons, cannot receive education in the traditional way. In addition, the advantage of this form of education is the lack of «age requirements», which is sometimes an objective obstacle to retraining or additional education for those categories of people with professional experience. The purpose of the study was to analyze the features of teaching a distance course in the discipline «Laboratory Diagnostics», developed at the Department of Clinical Laboratory Diagnostics National university of pharmacy. Material and methods. The methodological basis of the study included the following components: system approach; the concept of personality-oriented learning; principles of distance learning; theory of information systems. The article considers the peculiarities of the organization of distance learning in National university of pharmacy, the main methodological regulations on which the introduction of distance learning courses is based. The distance courses of the discipline «Laboratory Diagnostics» for students of specialty 226 «Pharmacy, Industrial Pharmacy» in the information environment Moodle was analyzed and generalized and the basic elements of educational information placement were directly described. The authors determined the place of distance courses in the process of independent training of educational process; the special role of the teacher (tutor) in the organization of independent training of the students according to the offered methodical recommendations and distance courses was shown. Conclusion. Distance learning in a virtual educational environment provides a variety of modern e-learning tools that can be used not only in full-scale distance learning, but also in traditional forms. National university of pharmacy is actively implementing measures to comply with the requirements of current regulations of the Ministry of Education and Science of Ukraine on the implementation of distance learning. The experience of teaching the discipline «Laboratory Diagnostics» using distance learning technology allows future professionals in the field of knowledge «Health» to acquire skills and abilities
The observation of secondary СV-СVI haematogenic osteomyelit, forming prevertebral abscess, that led to pathological fracture with compression of spinal cord and sepsis are described. The treatment features were given. Âòîðèííèй ãåìàòîãåííèй îñòåî쳺ë³ò ÑV-ÑVI õðåбö³â ç ôîðìóâàííÿì ïðåâåðòåбðàëüíîãî àбñöåñó òà ïàòîëîã³чíîãî ïåðåëîìó ç êîìïðåñ³ºþ ñïèííîãî ìîçêó
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.