Мета огляду — аналіз даних літератури щодо поширеності, етіології, генетики, патогенезу синдрому Жильбера. Проведений огляд наукової літератури щодо синдрому Жильбера за ключовими словами «синдром Жильбера», «гіпербілірубінемія», «уридиндифосфатглюкуронілтрансфераза» з використанням як пошукової системи PubMed. Беручи до уваги дослідження, проведені в останні 10 років, проаналізовані тези 75 статей. Більш детально вивчено результати дослідження, висвітлені у 28 статтях.
Les indicateurs de protéines métalliques (transferrine, céruloplasmine) chez les enfants avec surpoids et obésité Introduction. Dans tous les pays, on observe une augmentation progressive du nombre de patients obèses, tant chez les adultes que chez les enfants. Aujourd'hui, l'obésité est considérée comme une inflammation systémique chronique de faible activité. Actuellement, il existe une accumulation d'informations sur la signification biologique et clinique des protéines métalliques dans ce processus inflammatoire. But. Étudier les effets de la transferrine et de la céruloplasmine chez les enfants avec surpoids et obèses.
Paramètres immunologiques et niveaux du cortisol chez les enfants avec dermatite atopique Introduction. La contribution des cytokines individuelles dans la formation de différentes formes cliniques de la dermatite atopique (AD), les effets du cortisol sur ce processus chez les enfants ont été insuffisamment étudiés. Le but de l'étude. L'investigation des violations de l'immunité cellulaire et humorale et le contenu de cytokines et de cortisol chez les enfants atteints de la MA. Méthodes. 168 enfants âgés de 1 à 18 ans atteints de BP ont été examinés. La détermination de CD3, CD4, CD8 CD16 CD19 a été réalisée par la cytofluormétrie d'écoulement, la concentration des IgA, IgM, IgG, IgE, l'IL-2, IL-4, IL-6, IL-10, INF-, Cortisol ELISA. Le programme Excel, Statistica 6.0 et le calculateur SISA en ligne ont été utilisés. Les valeurs moyennes présentées sous la forme de (M ± m), où M-le taux moyen, m-erreur standard de la moyenne; n-le volume du groupe analysé.
The relevance of this study is due to the desire to propose one of the criteria that contributes to improving the effective communication with a patient: analyzing and interpreting patient’s emotional speech. The aim of this paper is to consider the usage features of figurative and expressive means in a patient’s speech which may characterize both the sick state and his attitude to health problems. To achieve this aim the following methods are used in the paper: distributive, contextual, semantic and stylistic methods. The material for analysis is the patent’s phrases taken from the various sources: real and designed for classes communication situations, mass media, teaching aids and science articles on the medical discourse. A patient is an equal partner in the communication with a doctor that is why the consideration of linguistic and paralinguistic factors influencing the patient’s choice of speech means is no less important. When studying the patient’s speech expressive means can be distinguished at all levels of the language: phonetic, morphemic, lexical and grammatical. Doctor’s understanding the explication of the patient’s intentions and analyzing the patient’s speech expressive means contribute to correct interpreting the patient’s story about himself and his state of health. We believe that the patient’s thinking creativity being expressed in using the emotional means is due to, on the one hand, his inability to describe internal pain sensations properly in detail. On the other hand, in the situation of a strong pain it is due to the patient’s desire to quickly find the right metaphor or other means to express his thought by a non-standard way that implies more emotionally and thus increases the function of influencing the interlocutor and creates more positive emotional background in communication with a doctor.
Urinary tract infections (UTIs) remain an urgent issue in clinical pediatrics. Empirical selection of antibacterial therapy becomes more complicated, and antibacterial drug indication is not always clinically substantiated. This study aimed to compare the antibacterial susceptibility pattern of the main group of urinary tract infectious agents from 2009–2016 with intermediate results from 2020–2021, during the COVID-19 pandemic, among children in the Chernivtsi region. Urine samples were collected from 3089 children (0–17 years old) treated at the health care institutions in the Chernivtsi region (2009–2016). The clinical-laboratory examination of 177 children (0–17 years old) was carried out from 2020 to 2021. The children received specialized medical care at the Department of Nephrology. Preliminary data of regional monitoring (2020–2021) are not considerably different from the previous regional susceptibility of antibiotics: to penicillin (p<0.01), ІІ-ІІІ generation cephalosporin (p<0.01); an increased resistance to levofloxacin (χ2=4,338; p<0.01), tetracycline – χ2=7,277; p<0.01; doxycycline – χ2=5,309; p<0.01) and imipenem – χ2=5,594; p<0.01). The data obtained did not explain an increased resistance to fluoroquinolones completely (ofloxacin, pefloxacin, ciprofloxacin), except for levofloxacin (χ2=4,338; p<0.01). A reliable difference of susceptibility of tetracycline group was registered (tetracycline – χ2=7,277; p<0.01; doxycycline – χ2=5,309; p<0.01). Furthermore, there was a regional increase in some UTI-pathogen strains resistant to carbapenems (imipenem – χ2=5,594; p<0.01). The use of antibiotics from the group of penicillins and II-III generation cephalosporins as the starting antibacterial therapy for STIs during the COVID-19 pandemic should be justified. A regional increase (2020–2021) of some uropathogenic strains resistant to carbapenems administered to treat severe bacterial infections requires their exclusively designated purpose in everyday pediatric practical work.
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