Introduction. In chronic cerebrovascular diseases (CVD), neuroprotective medications, the effectiveness of which requires further study, are widely used. The effectiveness of Cytoflavinum in patients with chronic CVD was evaluated.Material and methods. The data of 60 patients (35 women and 25 men) with chronic CVD were analyzed. 30 patients, included in the main group (mean age 61 ± 5.87 years old), in addition to basic therapy (antihypertensive, antithrombotic drugs, statins), received Cytoflavinum according to the following scheme: 1 time a day in the morning intravenously 10.0 ml for 10 days, then 2 tablets 2 times a day for 30 days. 30 patients in the comparison group (mean age 59.8 ± 8.7 years old) received only basic therapy. An analysis of patient complaints, neurological status was carried out. Mini Mental State Examination (MMSE), the Montreal Cognitive Assessment (MoCA), Hospital Anxiety and Depression Scale (HADS) were used.Results. In the group of patients taking Cytoflavinum, there was a decrease in the frequency and intensity of headache, dizziness, an increase in MMSE score from 26.32 ± 0.86 to 28.05 ± 1.36 (p ≤ 0.05), in MoCA score from 25.35 ± 0.96 to 27.88 ± 1.13 (p ≤ 0.05), decrease in anxiety score from 8.82 ± 1.31 to 5.2 ± 2.82 (p ≤ 0.05) and decrease in HADS depression score from 8.31 ± 1.85 to 4.6 ± 3.15 (p ≤ 0.05).Conclusion. The inclusion of Cytoflavinum in the treatment regimen for patients with chronic CVD helps to reduce the frequency and intensity of headaches and dizziness, improve cognitive functions, and reduce the level of anxiety and depression.
Aim of research: to study the comparative effectiveness of new polycompositive of hemostatic implant on in vivo model of liver parenchymal bleeding.Material and methods. Experimental studies were performed using the developed polycompositive hemostatic implant (CPM) from cellulose derivatives. Main components of implant include: natrium carboxymethylcellulose, oxidized cellulose, nanocellulose and bonded calcium ions. In vivo experiments were conducted in both sexes white 24 utbred rats weighing 196.5 ± 2.8 grams. The animals were divided into two groups: the comparative group (n = 24) with an application of polycomposite hemostatic implant and main group (n = 24) with medical gauze. The hemostatic materials were used in equal weight 30 mg. All surgical procedures on animals were performed under general inhalation anesthesia in model of liver parenchymal bleeding.Results. Thus, hemostasis was reached within 34.0 ± 2.5 seconds in the main group with CPM, in the comparative group with medical gauze — 142.2±7.7 seconds. Repeated bleeding was observed in 11 (45.8%) cases of the comparative group and in the main group — 2 (8.3%) cases. Biodegradation of the hemostatic implant and regenerative processes in the liver parenchyma were registered on the 14 day, especially in the injured area that indicates the restoration of liver tissue. In the comparative group on the 30th day, the preservation of medical gauze structure was revealed without degradation signs.Findings. According to our research data, a polycompositive hemostatic implant adheres tightly to the liver tissue, stops bleeding without its recurrence. In histological studies conducted in the dynamics of wound healing of the liver it was found that the implant does not cause a severe inflammatory reaction and biodegradation occurs after 14 days.
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