Background/Aim: In chronic spontaneous urticaria (CSU), Helicobacter pylori (HP) has been discussed as a cause, but it is unknown whether the bacterium itself or concomitant inflammation is causing the urticaria. Our aim was to investigate HP and upper gastrointestinal lesions as signs of inflammation independently of each other in the pathogenesis of CSU. Methods: A total of 36 prospectively enrolled CSU patients from Moscow were investigated by gastroscopy and screened for the presence of HP and/or upper gastrointestinal lesions. Those having a positive result were treated according to the Maastricht III recommended guidelines for eradication therapy, and success was assessed by a follow-up gastroscopy. Simultaneously, the activity of CSU was measured before and after therapy of the gastrointestinal condition. Results: HP was observed in 26 of the 36 patients. Erosions or ulcers were found in 18 of the 36 patients, 14 of whom were also positively tested for HP. There was a significant difference in improvement of urticarial symptoms between those who succeeded in healing the erosions and those who did not succeed (p < 0.01) independent of the presence of HP. No significant difference in symptom relief was observed between those who had successful eradication and those in whom HP eradication failed. Conclusions: Upper gastrointestinal inflammatory disorders can cause CSU and trigger exacerbations independently of HP. This might imply that also in HP-positive patients, urticaria is not based on an immunological reaction against the germ but rather on the underlying inflammation. These findings also strengthen the importance of a gastroenterological workup of patients with CSU.
The aimof this study was to evaluate real social functioning of patients in remission of paranoid schizophrenia in the dynamics of treatment and rehabilitation measures.
Methods.Patients of the medical rehabilitation department were included in the transverse clinical and population study. Clinical scale evaluation was used, including PANSS, PSP.
Results.It was shown that patients with schizophrenia included in the program of therapeutic and rehabilitative measures, met clinical and functional criteria of remission. Negative symptomatology prevailed in the clinical picture and was more present in male patients. Individual negative symptoms were associated with the effectiveness of rehabilitation. Despite the generally comparable level of social functioning in patients of different sexes, functioning in different spheres is mediated by the gender factor. Factors associated with the social functioning of patients include employment, experience of own family and independent living. As a result of treatment and rehabilitation measures, there is a tendency to decrease the severity of positive and negative symptoms, a reliable decrease in the severity of depressive symptoms and an increase in the level of social functioning of patients.
Conclusions.The clinical and functional characteristics of schizophrenia remission are gender-specific. Differentiated assessment of patients social functioning should include professional and microsocial adaptation. The criteria for evaluation of the effectiveness of treatment and rehabilitation measures in remission of schizophrenia include reduction of the severity of residual symptoms and increase in the level of social functioning of patients.
The hygienic assessment of working conditions at the modern furniture company showed such conditions at main work places are referred to the third class of the first and second degrees of the hazard and danger. The most adverse working conditions (3 class, 2 degree) are typical for operators of woodworking machines, machine operator in a spray booth for the edges of the sorter-stacker at the discharge conveyor line trim boards and spray the frames, the sorter-stacker at the feed conveyor panels of finish line rollers. Man-made noise, low lightness of working places, and the hardness of the labor process are most harmful occupational factors. Implementation of paint operations on processing of furniture components is further accompanied by the air pollution of the working area by chemicals and exposure of the body of the worker to the heating microclimate of radiation-convection type. Most of workplaces are characterized by summing the classes of working conditions on a number of factors. It indicates to their complex impact on the body of the worker. The assessment of the risk of occupational hearing loss showed the most probability of its development in machine operators and packers.
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