Modern Biological Methods Of Diagnosis Of Mental Disorders

Петрова, Н Н; Бутома, Б. Г.

doi:10.15216/978-5-4365-0174-1

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“…For various reasons, 12 previously-involved patients were subsequently excluded from the study. Diagnosis: psychological and behavioural disorders due to alcohol abuse were based on the criteria of the Consortium for the development of diagnostic criteria for Al addiction (Goffman, Meliksetian, & Orlova, 2010;Petrova, 2015) and verified by the Bureau of Medical and Social Expertise at Ivano-Frankivsk Psychoneurological Dispensary.…”

Section: The Methods and The Organization Of The Researchmentioning

confidence: 99%

Untitled

2019

JPES

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The pathogenesis of illness associated with alcohol abuse plays an important role not so much in the duration of alcoholic beverages consumption by patients, as in the oxidative stress in different cells. Erythrocytes of peripheral blood are considered to be passive 'informative cells', and patients with psychological and behavioral disorders due to alcohol abuse have not been studied sufficiently. One of the tasks of this work was to find out through which component the activity of the antioxidant system and the structural state of erythrocytes in people with psychological and behavioral disorders due to alcohol abuse changes. It has been shown that in people with psychological and behavioral disorders due to alcohol abuse oxidative stress in peripheral blood erythrocytes increases, which is manifested by an increase in the concentration of H 2 O 2 and organic hydroperoxides, as well as a decrease in the ratio of glutathione / glutathione disulfide and glutathione transferase activity. Increasing the size of peripheral blood erythrocytes against the background of decreased activity of glutathione peroxidase can serve as a reliable marker for alcohol addiction, and changes in other indicators of oxidative stress reflect nonspecific violations, probably from hepatocytes responsible for saturation of peripheral blood erythrocytes with appropriate antioxidants.

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Section: The Methods and The Organization Of The Researchmentioning

confidence: 99%

Untitled

2019

JPES

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Modern Biological Methods Of Diagnosis Of Mental Disorders

Cited by 1 publication

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