Aim. To evaluate 24-hour dynamics of the arterial stiffness main indicators in patients with arterial hypertension associated with metabolic syndrome, coronary heart disease and type 2 diabetes mellitus.Methods. The study included 54 patients with hypertension, who formed main groups: the first group - 17 patients with hypertension amid the metabolic syndrome, the second - 21 patients with metabolic syndrome and coronary heart disease, the third group - 16 patients with hypertension and type 2 diabetes mellitus. All patients underwent the vascular stiffness parameters study using a multifunctional complex for the 24-hour monitoring and office measurements of blood pressure and vessels condition. At the same time blood pressure, cardiac function and vascular stiffness indicators were examined: PWVao - pulse wave velocity in the aorta (m/s); PWTT - the pulse wave transit time (m/s); Aix - augmentation index (%); Asi - the arterial stiffness index. (mmHg).Results. When comparing the 24-hour arterial stiffness dynamics indicators, changes were found in all main patients groups compared to the healthy group. Thus, a statistically significant increase in the pulse wave velocity in the aorta (PWVao) in all groups of patients compared with the control group, a decrease in the index of the pulse wave transit time (PWTT) in all main groups of patients and a significant increase in arterial stiffness index (Asi) were found. When assessing the results of arterial stiffness monitoring at night time significantly larger values of the pulse wave velocity in the aorta were observed in patients with the metabolic syndrome and combination of metabolic syndrome and coronary heart disease. The obtained data are indicative of improvement in vascular stiffness indicators at night time in healthy individuals group, as well as maintaining a high degree of the vascular wall stiffness both in the night and in the daytime in a group of examined patients, especially in groups with the metabolic syndrome, and a combination of metabolic syndrome and coronary heart disease.Conclusion. 24-hour monitoring of vascular stiffness indicators in comorbid patients have revealed variability of the main indicators during the day; such arterial stiffness indicators as the pulse wave transit time, pulse wave velocity in the aorta, the arterial stiffness index, augmentation index can be used to assess early signs of the major arteries remodeling.

Aim. To study the influence of type of behavioral activity on the development of cardiovascular diseases, to evaluate the effect of type of behavior on the frequency of repeated hospitalizations and fatal outcomes after acute coronary syndrome. Materials and methods. The study included 100 patients with acute coronary syndrome who were subsequently divided into groups according to the main disease - acute myocardial infarction and unstable angina. The median age was 62.09±5.46 years, the therapy according to the underlying disease. All patients had anamnesis of previous and concomitant diseases, anthropometric measurements, physical examination, and observation during the next 24 months after inclusion in the study. In dynamics he carried out daily monitoring of electrocardiogramm, daily monitoring of blood pressure, echocardiography. Diagnosis of types of behavioral activity was carried out using the test method "type of behavioral activity" developed on the basis of the questionnaire Jenkins Activity Survey, published in 1974 by C. Jenkins, the Russian-language adaptation was performed in NIPNI Bekhtereva (L.I. Wasserman, N.V. Gumenyuk). Results. In patients with behavioral activity type A more frequent occurrence of diseases such as angina, hypertension, acute myocardial infarction, acute violation of cerebral circulation, type 2 diabetes than in persons with behavior type AB and B. Repeated hospitalizations for unstable blood pressure and unstable angina on the background of standard therapy in patients with type a behavior occur more often than in patients with type AB and B.

No abstract