Improving the efficacy of the renal diseases treatment is an important problem in the medical and pharmaceutical practice. The first place in this group of diseases occupied by chronic kidney disease (CKD), since it is not only the most common pathology of the urinary system, but also has a great medical
ABSTRACTThe study was devoted to the evaluation of dose-dependent efficacy of N-acetylglucosamine and quercetin combination in the treatment of renal failure. The combination was studied in injectable dosage form at the doses of 10, 20, 40 and 60 mg/kg in rats with chromium-induced nephropathy. The efficacy of combination was assessed by animal survival, renal excretory function, nitrogen metabolism and nephroprotective activity. Also, the ED 50 index was calculated by Probit Analysis method. The efficacy of combination at doses of 40 and 60 mg/kg was most expressed with insignificant differences (p>0.05) between them. There was a significance increase (p<0.05) in animal survival, renal excretory function and normalization of nitrogen metabolism. This led to the nephroprotective activity of 67.8 and 70.4%, respectively. The ED 50 index of combination was 30.2 ± 6.3 mg/ kg. Thus, this test combination at a dose of 30.2 mg/kg is the promising drug for experimental treatment of kidney diseases.
In recent years, the system of cytokines has a significant role in forming and progressing chronic heart failure of various etiologies (ischemic, inflammatory, infectious and allergic, etc.). Aim. To study the activity of proinflammatory cytokines (interleukin-1α (Il-1α), interleukin-1β (Il-1β), interleukin-6 (Il-6) and interleukin-8 (Il-8) and anti-inflammatory cytokine (interleukin-4 (Il-4) in heart failure (HF) in thyrotoxicosis patients. Materials and methods. 64 patients and 20 healthy volunteers were examined; they were distributed in 3 groups: group I (44 patients) patients with thyroid cardiomyopathy, group II (20) patients with no sign of cardiomyopathy and group III-20 healthy volunteers. The serum levels of interleukines 1α, 1β, 4, 6 and 8 at admission, in 21 days and 6 months were measured. Results. The level of IL-6 and IL-8 were significantly higher in patients with thyrotoxic HF compared to those without HF and healthy subjects. Correlation in Il-6 and Il-8 serum levels and severity and duration of HF were revealed. No correlation in Il-4 serum levels and HF was found. Conclusions. It can be assumed that Il-6 and Il-8 are involved in the progression of heart failure and, less likely, in the formation of cardiomyopathy; however, for a more accurate identification of these regularities further studies are required.
Mean (SD) reduction from baseline at Month 6 for users of all latanoprost formulations (preserved and PF) was 6.1 (4.25) mmHg (25.9%; p \ 0.0001).The authors have also prepared a table to summarise the change in intraocular pressure following a switch to the preservative-free tafluprost/timolol fixed-dose combination from all latanoprost formulations (preserved and
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