Abstract. We have undertaken a comprehensive comparative assessment of quantitative relationships between the contribution of environmental anthropogenic factors and the indicators of individual and population carcinogenic and non-carcinogenic risks. This assessment confirms the influence of the major anthropogenic factors on children's health in single factory towns.
Improving the effectiveness of drug therapy and reducing the risk of adverse cardiovascular and renal outcomes in patients with resistant hypertension (HTN) remains an unsolved problem of cardiology. The results of the PATHWAY-2, PATHWAY-3 and ReHOT studies have shown the clinical efficacy of spironolactone, amiloride and, to a lesser extent, the antiadrenergic drugs clonidine, bisoprolol and doxazosin in improving blood pressure (BP) control in this patient population. However, the inclusion of spironolactone and other known drugs in antihypertensive therapy does not ensure the achievement of target BP level in a significant proportion of these patients. The review presents the results of clinical studies of new approaches aimed at increasing the effectiveness of drug therapy in resistant HTN including sodium-glucose cotransporter type 2 inhibitors, brain aminopeptidase A inhibitors, and new antagonists of endothelin receptors.
The hygienic assessment of the maintenance of contaminants in food and the risk assessment of influence of food products on health of the population of the Orenburg Region has been carried out. Groups of products making the greatest contribution to the exposition to the studied chemicals and to the development of cancerogenic and non-cancerogenic risk for the population health have been defined. The received results are used for the improvement of the state sanitary and epidemiologic supervision and taking administrative decisions.
This article was written on the base of the analysis of data of protocols of annual serological sturdies of the postvaccination immunity status in indicator groups of populations, the analysis of samples of drinking water, air and soil with the assessment of the socio-economic development of mono-towns and rural settlements. In the article there is reflected the comprehensive assessment of environmental factors and specific features of the formation of socioeconomic conditions of rural communities and mono towns. There was performed a comparative assessment of the status of post-vaccination immunity to infections controlled by specific means of prevention, in different age groups in mono towns and rural settlements. There was established a dependence of the formation ofpost-vaccination immunity on the state of environmental factors.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.