Spasticity treatment is one of the key aspects of the contemporary cerebral palsy (CP) rehabilitation that influences on the effectiveness of other methods. The paper presents the first Russian document that unites the recommendations for the BTA treatment of CP and could be used as the guideline for the multilevel injections. The Russian consensus on the multilevel botulinum toxin A (BTA) treatment of spastic CP is based on the international data and the results of national studies. The authors describe typical CP spasticity patterns in the upper and lower extremities, give recommended intervals for the BTA (Abobotulinum toxin A) dosages for the whole injection procedure and for the separate muscles. The method of dosage calculation for functional segments is also described. Attention is paid to the frequency, optimal intervals between the repeated injections and the whole duration of BTA treatment. The authors discuss effectiveness and safety of BTA, factors that potentially influence the results of the injections, including ultrasound and electromyography control, and indications for the continuation and termination of treatment.
Psychometry plays an important role when determining the state of psychophysiological and cognitive functions in children of different ages. Goal. To deliver an original software package for a psychophysiological computer complex (PCC) “Psychomat” for implementing an online analysis of psychophysiological and cognitive functions in children of different ages. Materials and methods. One hundred eighty-four conditionally healthy school children aged 6 to 17 years were examined using a set of psychophysiological tests and original methods for evaluating higher mental functions (24 tests, 66 parameters). Results. An original software package as the computer psychophysiological complex “Psychomat” was elaborated. The norm base was determined. Also, the testing mechanism and scoring system in points for psychophysiological functions assessment were developed. Thus, it became possible to establish the patterns of cognitive and psychophysiological functions development at different ages. Conclusion. This newly created software package can be used as a test system for mass examination of children of different ages.
There was a trend towards an increase in the percentage of patients with positive changes (a decrease in the total ADHD-DSM-IV by ≥25%) in the end of the 3rd and 4th month in the pantogam group (treatment response was 66.7 and 68.9%, respectively) compared to the placebo group (treatment response was 52.3 and 61.4%, respectively). A significant decrease in disease severity assessed by the CGI-S was noted in the pantogam group compared to the placebo group. After 4 month of treatment with pantogam, the severity of functional disturbances was reduced by 4 out of 6 WFIRS-P domains: Family, School and learning, Child's self-concept and Risky activities. Pantogam improved the measures of sustained attention (accuracy and speed) in the Toulouse-Piéron test. The drug used in mean daily dose 30 mg/kg during 4 month had a favorable safety profile which did not differ from that of placebo.
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