How do arbitrary signs occur? The article suggests that the basis of arbitrariness is the liberation of the signified from a rigid connection with the signifier. An important role is played by the psychological present. The psychological present is not one-dimensional but is represented by dimensions of sequence, simultaneity, and duration. Non-arbitrary signs are as if one-dimensional: the signifier and the signified are in undifferentiated unity – in one dimension of the present time. When forming arbitrary signs, the signified and the signifier are separated from each other and are embodied in different dimensions – the levels of the psychological present tense, invariant and variable. At the same time, the signified occupies an invariant level, and the signifier is variable so that the signified remains constant with any change in the signifier. Therefore, different signifiers can be applied to the same object at will, and the content of the designated object does not change. The signified thus becomes relatively independent and free from the signifier.
In our article, we studied the concentration of immunoglobulins, the interleukin system and observed their changes before and after our patented treatment with a dressing based on "Placentol". The study material was the oral fluid of the patients. We observed 67 patients with a diagnosis of chronic generalized periodontitis of mild severity from 214 employees. The patients are workers of the limestone quarry. We revealed the occupational conditionality of the disease by chronic generalized periodontitis in workers of the limestone quarry, which turned out to be highly conditioned (that is, working conditions affect the condition of the periodontal). The results of the treatment pleased us, we achieved clinical improvement on the fourth visit. The work of the periodontal immune system is partly determined by the direction of the development of pathological processes in chronic inflammation. The main cause in the pathogenesis of chronic immunological inflammation can be a local disorder at the level of the mucosal system or small abnormalities at the systemic level. This task is complex and it is studied both from the immunological position and from the position of general pathology, taking into account the functioning of other homeostatic systems of the body. The article also provides information on the role of cytokines in the pathogenetic mechanisms of chronic inflammation in periodontal tissues, and how our patented treatment can enhance the oral immune system. Also, to carry out early diagnosis and prevention of periodontitis in limestone quarry workers, identifying their relative risk index and the etiological proportion of periodontitis incidence. The aim of our work is to study the changes in the parameters of the oral cavity immune system, under the influence of the treatment of the Placentol dressing, in the workers of the limestone quarry, and in the future to offer them our treatment.
Резюме Цель: определение цитокинового профиля в сыворотке крови у больных с тяжелым течением геморрагической лихорадки с почечным синдромом, осложненной острой почечной недостаточностью Материалы и методы. Обследуемые лица были разделены на контрольную группу -46 человек (здоровые), группу пациентов со средней тяжестью заболевания -35 человек и группу пациентов с заболеванием тяжелой степени, осложненной острой почечной недостаточностью, -38 чел. У обследуемых отбиралась кровь на исследование цитокинов. Определение цитокинов осуществлялось методом иммуноферментного анализа с применением тест-наборов в соответствии с инструкцией производителей. Результаты. У больных геморрагической лихорадкой с почечным синдромом, как средней, так и тяжелой степени, отмечалось повышение интерлейкинов IL-1β, IL-6, IL-10 по сравнению с контрольной группой. Однако значения данных интерлейкинов были достоверно выше у пациентов с тяжелым течением геморрагической лихорадки, осложненной острой почечной недостаточностью по сравнению с группой пациентов со средней тяжестью. Значения IL-8, IFN-γ и SDF-1a изменялись только у пациентов с тяжелым течением. При этом отмечалось усиление экспрессии IL-8 и снижение IFN-γ по сравнению с контрольной группой. У пациентов, только поступивших в стационар, а также пациентов средней степени тяжести IL-8 и IFN-γ статистически не менялись. Специ фичным для пациентов с тяжелым течением заболевания также оказалось изменение хемокина SDF-1a: его значения возрастали в сравнении с контрольной группой. У пациентов, только поступивших в стационар, а также в группе больных со средней степенью тяжести заболевания достоверных изменений SDF-1a выявлено не было. Заключение. Полученные результаты свидетельствуют о диагностической ценности определения
Objectives. Analysis of oral fluid in children with congenital cleft palate and palate defect after uranoplasty. Purpose. To analyze oral fluid in children with congenital cleft palate and palate defect after uranoplasty to determine the levels of pro-inflammatory (IL-1β, IL-6, TNF-α) and anti-inflammatory (IL-4, IL-10) cytokines and secretory immunoglobulin sIgA and evaluate physico-chemical (salivation rate, kinematic viscosity, pH) and biochemical parameters (calcium, magnesium, phosphorus, protein) of mixed saliva. Methodology. The article presents the results of studying the parameters of the oral fluid of 109 children aged 6–12 years with congenital cleft palate and palate defect after uranoplasty and 50 practically healthy children of the same age. Results. Hyperstimulation of pro-inflammatory (IL-1β, IL-6, TNF-α) and anti-inflammatory (IL-4, IL-10) cytokines in the oral fluid and a decrease in the average level of secretory immunoglobulin sIgA. In children with congenital cleft palate and defects remaining after uranoplasty, there was a deviation in the physicochemical and biochemical parameters of the oral fluid, which are manifested by a decrease in the rate of salivation, an increase in its viscosity and a shift in pH to the acid side. In contrast to the group of children without dental pathology, children with cleft palate and defects after uranoplasty showed a decrease in the content of total protein, phosphorus and calcium in the mixed saliva and an increase in the content of magnesium. Conclusions. The obtained laboratory data indicate the presence of a local inflammatory process in the oral cavity and a decrease in local immunological anti-inflammatory factors. This should be taken into account for the development of methods for preoperative sanitation of the oral mucosa in children with congenital cleft palate and a palate defect after uranoplasty at the stage of preparation for reoperation.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.