No abstract

The article is devoted to the problem of developing social and communicative competence of future teachers in the process of their professional training. The definition of the concepts of “social and communicative competence”, “professional training of a teacher” is given. The development of the social and communicative competence of a future teacher in the process of his professional training, which is understood as an integral neoformation of a teacher’s personality, being characterized by a set of theoretical, linguistic and methodological knowledge on the development of social and communicative competence of future teachers in the process of his professional training, was considered. Pedagogical conditions for the development of social and communicative competence of future teachers in the process of their professional training were revealed. The results of the experimental work showed that if the pedagogical conditions are observed, future teachers in educational organizations have an increased desire to develop social and communicative competences and strive for achieving effective skills of interpersonal interaction and communication, as well as for knowledge of the methodological foundations and categories of pedagogy, patterns of development and formation of students’ personalities.

No abstract

The article describes features of the formation of future teachers’ information culture. The relevance of the development, implementation and maintenance of the technology of forming process of information culture of future teachers is substantiated. Different views of scientists on the definitions of “information culture of a person”, “technology” are considered. The main components of information culture are highlighted: computer literacy, information competence, information reflection, information culture creation. The constituent elements of pedagogical technology are listed, which is represented by a set of goals and methods aimed at implementing the projected learning process and is presented by a phased implementation plan. The main characteristics of a technology for the formation of information culture of a future educator are revealed and disclosed. The article describes the results of experimental work to identify the current level of formation of information culture of future teachers. Comparative results of the data obtained during the control experiment testify to the effectiveness of the probed technology and the readiness to use information technologies in professional activities.

To study the distribution of alleles and genotypes of polymorphic markers of genes CYP2C9 and VKORC1 of Russian patients who live in Moscow, and in order to assess the influence of genetic factors on warfarin therapy 400 patients have been genotyped. The dosage of warfarin which is required for achievement of INR target values has been different among owners of different geno- types of polymorphic markers of genes CYP2C9 . Meanwhile the highest average dose has been required for genotype *1/*1 and the lowest – for owners of alleles *2 and *3 . For polymorphism G(- 1639)A of the gene VKORC1 the dosage of warfarin which is required for achievement of the INR target values, has been different among owners of different genotypes. The highest average dose has been required for genotype GG, and the lowest – for genotype AA. The results will allow to work out more accurate algorithm of choosing of the initial dose of warfarin depending on the genotypes of polymorphic markers of genes CYP2C9 and VKORC1.

The article deals with the problem of future primary school teachers’ research skills development. The relevance of the studied problem is justified by the need to form the research skills of future primary school teachers, which is one of the requirements of their professional training in higher education formulated in the Federal state educational standard (FSES) and the Professional standard of the teacher-teacher of primary school education. The aim of the article was to develop a methodical system of future primary school teachers’ research skills development in higher education, as well as process description of its experimental implementation in the educational process of the University. The research methodology includes such methods as pedagogical experiment, diagnostics, approbation, analysis, generalization. In the course of the research the following theoretical results were achieved: the purpose, objectives, components of the methodological system of development, the qualitative result of its implementation, indicated technological support of the process of future educators’ research skills development. The results of the study allowed justifying the effectiveness of the developed system of future primary school teachers’ research skills development, its theoretical and practical value. The developed methodical system, due to the validity of its effectiveness, can be used in the practice of pedagogical universities in the process of future teachers’ readiness to carry out research activities.

Цель. Выявление ассоциации наследственных особенностей факторов вос-паления с риском неблагоприятного исхода у больных мерцательной арит-мией (МА). Материал и методы. Наблюдали 258 больных (68,5±0,67 лет) с неклапан-ной МА, фиксируя развитие ишемического инсульта, инфаркта миокарда, венозных и артериальных тромбоэмболий. Срок наблюдения составил 455±11,71 дней. Результаты. Факторами, независимо ассоциированными с развитием ишемического инсульта у больных, не получающих антикоагулянты (n=101), явилось носительство аллеля С полиморфного маркера rs2228145(А/С) гена рецептора ИЛ-6 (ОШ 13,25 ДИ 1,57-112,18, р=0,018), возраст ≥75 лет (ОШ 1,1, ДИ 1,008-1,2, р=0,032) и ФВ ЛЖ (ОШ 0,97 ДИ 0,94-0,99 р=0,027), с развитием "тромботической конечной точки" -СД (ОШ 4,3 ДИ 1,46-12,45 р=0,008), ФВ ЛЖ (ОШ 0,96 ДИ 0,94-0,98, р<0,0001) и носительство аллеля С полиморфного маркера rs2228145(А/С) гена рецептора ИЛ-6 (ОШ 4,03 ДИ 1,07-15,26, р=0,04). Не выявлено ассоциации с неблагоприятными исходами полиморфизма генов ИЛ-6 (G(-174)C и G(-572)C), ИЛ-10 (C(-819) T), ФНО (G(-238)A, G(-308)A и ФНОα rs180630). У получающих адекватную антикоагулянтную терапию (n=157) достоверной ассоциации полимор-физма гена рецептора ИЛ-6 с развитием неблагоприятных исходов также не выявлено. Заключение. Таким образом, носительство аллеля С полиморфного маркера rs2228145(А/С) гена рецептора ИЛ-6 может быть независимым маркером риска неблагоприятного исхода у больных с "неклапанной" МА, потенциально, позволяющим отбирать для лечения больных, не имеющих достаточного уровня риска по общепринятым шкалам. Aim. To reveal the association of hereditary specifics of inflammatory factors with the adverse risk in atrial fibrillation (AF). Material and methods. Totally 258 patients studied (68,5±0,67 y. o.) with nonvalvular AF, recording the events as ischemic stroke, myocardial infarction, venous and arterial thromboembolism. Mean follow-up was 455±11,71 days. Results. Factors that are independently associated with ischemic stroke development in patients not receiving anticoagulants (n=101), were the allele C of polymorphic marker rs2228145(А/С) of gene IL-6 receptor (OR 13,25 CI 1,18, р=0,018), age ≥75 y. o. (OR 1,1, CI 1,008-1,2, р=0,032) and EF LV (OR 0,97 CI 0,99 р=0,027), with a "thrombotic endpoint" development -DM (OR 4,3 CI 1,45 р=0,008), EF LV (OR 0,96 CI 0,98, р<0,0001) and carriage of allele C of polymorphic marker rs2228145(А/С) of receptor to IL-6 gene (OR 4,03 CI 1,(7)(8)(9)(10)(11)(12)(13)(14)(15)26, р=0,04). There was no association with adverse outcomes in genes IL-6 polymorphisms as (G(-174)C and G(-572)C), ИЛ-10 (C(-819)T), ФНО (G(-238)A, G(-308)A and ФНОα rs180630). In those receiving adequate anticoagulant therapy (n=157) there was no significant association of IL-6 receptor gene polymorphism with adverse outcomes. Conclusion.Therefore, the carriage of allele C of polymorphic marker rs2228145(А/С) of the IL-6 receptor gene might be an independent risk marker for adverse outcome in non-valvular AF, potentially, being a selection tool for thos...

С целью получения экспертного мнения по вопросам, связанным с актуальностью, протоколами и режимами антитромботической терапии у пациентов с COVID-19 на госпитальном и амбулаторном этапах лечения 25 июля 2020г была проведена Международная он-лайн встреча экспертов по научному обмену опытом.Группа экспертов различных специальностей (кардиологи, неврологи, эндокринологи, анестезиологи-реаниматологи), имеющих клинический опыт лечения пациентов с COVID-19, ответила на вопросы, касающиеся использования антикоагулянтов на различных этапах оказания помощи при COVID-19. Учитывая недостаточное количество структурированной научной информации, отсутствие рандомизированных контролируемых исследований в области использования антикоагулянтов у пациентов с COVID-19, наличие различных мнений в профессиональных медицинских сообществах было принято решение провести голосование с использованием Дельфийского метода экспертных оценок и прогнозирования. На первом этапе для экспертов формировались вопросы, которые касались нескольких областей терапии: тактика ведения больных, постоянно принимавших антикоагулянты до заболевания COVID-19, назначение антикоагулянтной терапии больным по поводу COVID-19 и особенности назначения антикоагулянтной терапии у больных с высоким риском венозной тромбоэмболии при COVID-19. После утверждения списка вопросов проводилось анонимное анкетирование экспертов вне очной встречи и затем обрабатывались полученные результаты, определяя обычное большинство при голосовании по каждому вопросу.