IntroductionThis article presents the results of an international, multicenter, randomized, double-masked, placebo-controlled clinical study of Visomitin (Mitotech LLC, Moscow, Russian Federation) eye drops in patients with dry eye syndrome (DES). Visomitin is the first registered (in Russia) drug with a mitochondria-targeted antioxidant (SkQ1) as the active ingredient.MethodsIn this multicenter (10 sites) study of 240 subjects with DES, study drug (Visomitin or placebo) was self-administered three times daily (TID) for 6 weeks, followed by a 6-week follow-up period. Seven in-office study visits occurred every 2 weeks during both the treatment and follow-up periods. Efficacy measures included Schirmer’s test, tear break-up time, fluorescein staining, meniscus height, and visual acuity. Safety measures included adverse events, slit lamp biomicroscopy, tonometry, blood pressure, and heart rate. Tolerability was also evaluated.ResultsThis clinical study showed the effectiveness of Visomitin eye drops in the treatment of signs and symptoms of DES compared with placebo. The study showed that a 6-week course of TID topical instillation of Visomitin significantly improved the functional state of the cornea; Visomitin increased tear film stability and reduced corneal damage. Significant reduction of dry eye symptoms (such as dryness, burning, grittiness, and blurred vision) was also observed.ConclusionBased on the results of this study, Visomitin is effective and safe for use in eye patients with DES for protection from corneal damage.FundingMitotech LLC.

The frequency of myopia reached 26 % among of school graduates in 2000. In case of graduates from gymnasiums and lyceums — 50 %. The share of severe form of myopia 10–12 %. A pilot study was conducted. The prevalence of myopia was estimated in schoolchildren of 1, 5 and 11 classes in some Russian regions (Moscow, St. Petersburg, Igevsk, Ivanovo). Objectively cycloplegic refraction was studied in 3659 schoolchildren. During the entire period of being at school emmetropia was the most common type of refraction. In 5 and 11 classes myopia was more often refractive errors. The prevalence of myopia among 1th classes schoolchildren was 2.4 %, among 5th classes — 19.7 %, 11th classes — 38.6 %. In children studying in lyceums the prevalence of myopia was significantly higher (p < 0.01). Already in the 1 classes of gymnasiums and lyceums myopic children were 7.5 %, while in regular schools only 1.4 %. In 11 classes of lyceums the share of myopic children was 50.7%, in regular schools it was 30.9 %. This confirms the influence of education on the prevalence of myopia as an additive factor. The study of the myopia prevalence should be continued in different regions and municipalities to the subsequent development the rational programs for prevention of development and the progression of myopia in school.

The outcomes of hemorrhagic fever with renal syndrome (HFRS) were analyzed in 55 patients who were under the supervision of a physician – infectious within one year after the disease. This issue has been studied in more detail by the example of Hantaan virus infection in the Far East, the effects of Puumala infection aren’t well understood, vigilance among physicians concerning the formation of chronic kidney disease in patients is lacking. However, it is proved that the peculiarities of the clinical course of HFRS are caused by a specific serotype of the virus. It is revealed that the leading clinical manifestation in patients in early reconvalescence period of HFRS was astheno vegetative syndrome. Long-term prognosis of patients with HFRS, isn’t always favorable, it may be associated with prolonged disorders of the kidneys. Renal pathology includes lumbar – pain, eyelid swelling, dysuric phenomena, polyuria, nycturia, proteinuria, hematuria, cylindruria, reposotory. It is established that the disease is accompanied by a prolonged dysfunction of the nervous system, cardiovascular system, hepato-biliary system, this suggests the possibility of development of chronic pathology of different organs and the need for surveillance of HFRS patients, not only the infectious, but the nephrologist, cardiologist, neurologist.

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