Bronchial asthma (BA) is a disease that is one of the most frequent chronic diseases of childhood. Characteristic clinical symptoms of BA are wheezing, cough, difficulty in breathing, shortness of breath and, of course, recurrent episodes of bronchial obstruction. They require mandatory clarification of family and individual allergoanamnesis, assessment of symptoms, differential diagnosis with other diseases that may occur with BA. The Global Initiative for the Treatment and Prevention of Bronchial Asthma (GINA 20202021) preserves and develops the ageappropriate approach to verification of diagnosis and therapy selection, which is supported in the Russian National Program "Bronchial Asthma in Children" and in the Russian clinical guidelines "Bronchial Asthma 2021 When the diagnosis of BA is made, therapy should be started as early as possible. Administration of low-dose inhaled glucocorticosteroids (IGCS) immediately after the diagnosis allows not only to control the inflammatory process, which is the basis of BA, but also to reduce the severity of exacerbations. IGCS are the most effective drugs for children of any age, they ensure control of the disease and reduce the risk of AD exacerbations.
Эффективность монтелукаста натрия в терапии различных фенотипов бронхиальной астмы у детейНовосибирский государственный медицинский университет, кафедра педиатрии: 630091, Новосибирск, Красный пр т, 52 N.V.Kukhtinova, E.G.Kondyurina
Efficacy of sodium montelukast in treatment of childhood asthma of various phenotypes
SummaryEffects of 12 week course of sodium montelukast (Singular) on lung function, bronchial hyperresponsiveness and markers of eosinophilic inflam mation have been analyzed in children with atopic and non atopic asthma and recurrent bronchitis with allergic rhinitis. The study involved 69 chil dren aged 3 to 16 years. The study results showed that sodium montelukast significantly decreased lung hyperinflation and obstructive ventilatory disorders, recovered bronchial receptor sensitivity and controlled the eosinophilic inflammation. The effect was the most significant in children with non atopic asthma including the complete normalization of lung function. Key words: children, bronchial asthma, obstructive bronchitis, treatment, sodium montelukast.
РезюмеБыло проанализировано влияние 12 недельного курса приема монтелукаста натрия (Сингуляра) на параметры внешнего дыхания, показатели бронхиальной реактивности и маркеры эозинофильного воспаления у детей с атопической и неатопической астмой и повторным эпизодом бронхита, сочетающегося с аллергическим ринитом. В исследование были включены 69 детей в возрасте от 3 до 16 лет. Результаты исследования продемонстрировали, что монтелукаст натрия достоверно уменьшает гипервоздушность легочной ткани, устраняет обструктивный вентиляционный дефект, восстанавливает чувствительность рецепторного аппарата бронхов и конт ролирует активность эозинофильного воспаления. У детей с неатопической формой астмы положительное влияние на исследуемые параметры было максимальным, включая полное восстановление вентилируемых объемов. Ключевые слова: дети, бронхиальная астма, обструктивный бронхит, лечение, монтелукаст натрия.
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